Calcium and cancer:: targeting Ca2+ transport

被引：554
作者：
Monteith, Gregory R. [1 ]
McAndrew, Damara [1 ]
Faddy, Helen M. [1 ]
Roberts-Thomson, Sarah J. [1 ]
机构：
[1] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 07期
关键词：
D O I：
10.1038/nrc2171
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?
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收藏
页码：519 / 530
页数：12
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