Calcium and cancer:: targeting Ca2+ transport

被引：554
作者：
Monteith, Gregory R. [1 ]
McAndrew, Damara [1 ]
Faddy, Helen M. [1 ]
Roberts-Thomson, Sarah J. [1 ]
机构：
[1] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 07期
关键词：
D O I：
10.1038/nrc2171
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?
引用
收藏
页码：519 / 530
页数：12
相关论文
共 160 条
  • [1] Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells
    Arnuthan, G
    Biswas, G
    Ananadatheerthavarada, HK
    Vijayasarathy, C
    Shephard, HM
    Avadhani, NG
    [J]. ONCOGENE, 2002, 21 (51) : 7839 - 7849
  • [2] Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation
    Aung, Cho S.
    Kruger, Wade A.
    Poronnik, Philip
    Roberts-Thomson, Sarah J.
    Monteith, Gregory R.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 355 (04) : 932 - 936
  • [3] High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol
    Bandell, M
    Dubin, AE
    Petrus, MJ
    Orth, A
    Mathur, J
    Hwang, SW
    Patapoutian, A
    [J]. NATURE NEUROSCIENCE, 2006, 9 (04) : 493 - 500
  • [4] Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells -: Role in apical Ca2+ influx
    Bandyopadhyay, BC
    Swaim, WD
    Liu, XB
    Redman, RS
    Patterson, RL
    Ambudkar, IS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (13) : 12908 - 12916
  • [5] RESPONSES OF HUMAN NEUTROPHILS TO SULFITE
    BECKSPEIER, I
    LENZ, AG
    GODLESKI, JJ
    [J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1994, 41 (03): : 285 - 297
  • [6] Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay
    Behrendt, HJ
    Germann, T
    Gillen, C
    Hatt, H
    Jostock, R
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2004, 141 (04) : 737 - 745
  • [7] Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair
    Bentle, Melissa S.
    Reinicke, Kathryn E.
    Bey, Erik A.
    Spitz, Douglas R.
    Boothman, David A.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (44) : 33684 - 33696
  • [8] Calcium signalling: Dynamics, homeostasis and remodelling
    Berridge, MJ
    Bootman, MD
    Roderick, HL
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) : 517 - 529
  • [9] The AM and FM of calcium signalling
    Berridge, MJ
    [J]. NATURE, 1997, 386 (6627) : 759 - 760
  • [10] Calcium and 1,25(OH)2D:: interacting drivers of epidermal differentiation
    Bikle, DD
    Oda, Y
    Xie, Z
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 89-90 (1-5) : 355 - 360
12345678910