ROS in Cancer: The Burning Question

被引：402

作者：

Chio, Iok In Christine ^{[1
,2
]}

Tuveson, David A. ^{[1
,2
]}

机构：

[1] Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA

[2] Lustgarten Fdn, Pancreat Canc Res Lab, Cold Spring Harbor, NY 11724 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 05期

关键词：

MITOCHONDRIAL INTERMEMBRANE SPACE; DISULFIDE BOND FORMATION; CYSTEINE-SULFINIC ACID; TUMOR-SUPPRESSOR PTEN; OXYGEN-FREE-RADICALS; OXIDATIVE STRESS; PROSTATE-CANCER; HYDROGEN-PEROXIDE; THIOL OXIDATION; CELL-DEATH;

D O I：

10.1016/j.molmed.2017.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An unanswered question in human health is whether antioxidation prevents or promotes cancer. Antioxidation has historically been viewed as chemopreventive, but emerging evidence suggests that antioxidants may be supportive of neoplasia. We posit this contention to be rooted in the fact that ROS do not operate as one single biochemical entity, but as diverse secondary messengers in cancer cells. This cautions against therapeutic strategies to increase ROS at a global level. To leverage redox alterations towards the development of effective therapies necessitates the application of biophysical and biochemical approaches to define redox dynamics and to functionally elucidate specific oxidative modifications in cancer versus normal cells. An improved understanding of the sophisticated workings of redox biology is imperative to defeating cancer.

引用

页码：411 / 429

页数：19

共 214 条

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