A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers

被引：10

作者：

Ruiz-Manriquez, Luis M. ^{[1
]}

Ledesma Pacheco, Schoenstatt Janin ^{[1
]}

Medina-Gomez, Daniel ^{[1
]}

Uriostegui-Pena, Andrea G. ^{[1
]}

Estrada-Meza, Carolina ^{[1
]}

Bandyopadhyay, Anindya ^{[2
,3
]}

Pathak, Surajit ^{[4
]}

Banerjee, Antara ^{[4
]}

Chakraborty, Samik ^{[5
]}

Srivastava, Aashish ^{[6
]}

Paul, Sujay ^{[1
]}

机构：

[1] Tecnol Monterrey, Sch Sci & Engn, Campus Queretaro,Ave Epigmenio Gonzalez, Queretaro 76130, Mexico

[2] Int Rice Res Inst, Rice Ctr C4, Manila 4031, Philippines

[3] Reliance Ind Ltd, Synthet Biol Biofuel & Genome Editing R&D, Navi Mumbai 400701, India

[4] Chettinad Hosp & Res Inst CHRI, Chettinad Acad Res & Educ CARE, Dept Med Biotechnol, Fac Allied Hlth Sci, Chennai 603103, Tamil Nadu, India

[5] Harvard Med Sch, Boston Childrens Hosp, Div Nephrol, Boston, MA 02115 USA

[6] Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway

来源：

GENES | 2022年 / 13卷 / 02期

关键词：

microRNAs; cystic diseases; polycystic ovarian syndrome; polycystic kidney disease; pancreatic cyst tumors; biomarkers; POLYCYSTIC-OVARY-SYNDROME; GRANULOSA-CELLS; KIDNEY-DISEASE; PROLIFERATION; GROWTH; IDENTIFICATION; HYPERANDROGENISM; DIAGNOSIS; PROFILE; KLOTHO;

D O I：

10.3390/genes13020191

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

miRNAs are small endogenous conserved non-coding RNA molecules that regulate posttranscriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases are characterized by the presence of abnormal fluidfilled sacs in the body, and though most cysts are benign, they can grow inside tumors and turn malignant. Recent evidence has revealed that the aberrant expression of a number of miRNAs present in extracellular fluids, including plasma or serum, urine, saliva, follicular fluid, and semen, contribute to different cystic pathologies. This review aims to describe the role of different miRNAs in three worldwide relevant cystic diseases: polycystic ovarian syndrome (PCOS), polycystic kidney disease (PKD), and pancreatic cyst tumors (PCTs), as well as their potential use as novel biomarkers.

引用

页数：18

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