Comparative X-Ray Diffraction Studies of Indomethacin Solid Dispersions

被引：0

作者：

Nand, Pratibha ^{[1
]}

Drabu, Sushma ^{[1
]}

机构：

[1] Maharaja Surajmal Inst Pharm, New Delhi 110058, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2010年 / 22卷 / 04期

关键词：

Indomethacin; Urea; Mannitol; Sucrose; Dextrose; X-ray diffraction; Solid dispersions; DRUG-RELEASE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study focuses on comparative investigation of solid dispersion system consisting of drug and carrier in fresh as well as after storage at elevated temperature. Solid dispersions of a water-insoluble indomethacin with different water soluble carriers namely urea, mannitol, sucrose and dextrose were prepared. The samples were stored at a temperature of 40 +/- 1 degrees C for 2 months and results of X-ray diffractograms of fresh samples as well stored samples were compared. Samples of solid dispersion of mannitol-sucrose-indomethacin and mannitol-dextrose-indomethacin showed increased crystallinity.

引用

页码：3310 / 3312

页数：3

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