Parahydrogen-Based Hyperpolarization for Biomedicine

被引：257

作者：

Hoevener, Jan-Bernd ^{[1
]}

Pravdivtsev, Andrey N. ^{[1
]}

Kidd, Bryce ^{[2
]}

Bowers, C. Russell ^{[3
]}

Gloeggler, Stefan ^{[4
,5
]}

Kovtunov, Kirill V. ^{[6
,7
]}

Plaumann, Markus ^{[8
]}

Katz-Brull, Rachel ^{[9
]}

Buckenmaier, Kai ^{[10
]}

Jerschow, Alexej ^{[11
]}

Reineri, Francesca ^{[12
]}

Theis, Thomas ^{[13
,14
]}

Shchepin, Roman V. ^{[15
]}

Wagner, Shawn ^{[16
]}

Bhattacharya, Pratip ^{[17
]}

Zacharias, Niki M. ^{[17
]}

Chekmenev, Eduard Y. ^{[18
,19
,20
]}

机构：

[1] Univ Kiel, Univ Hosp Schleswig Holstein, Sect Biomed Imaging Mol Imaging North Competence, Ctr MOIN CC,Dept Radiol & Neuroradiol, Bot Garten 14, D-24118 Kiel, Germany

[2] Southern Illinois Univ, Dept Chem & Biochem, Carbondale, IL 62901 USA

[3] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

[4] Max Planck Inst Biophys Chem, Fassberg 11, D-37077 Gottingen, Germany

[5] Ctr Biostruct Imaging Neurodegenerat, Von Siebold Str 3A, D-37075 Gottingen, Germany

[6] Int Tomog Ctr SB RAS, Novosibirsk 630090, Russia

[7] Novosibirsk State Univ, Dept Nat Sci, Pirogova St 2, Novosibirsk 630090, Russia

[8] Otto von Guericke Univ, Dept Biometry & Med Informat, Leipziger Str 44, D-39120 Magdeburg, Germany

[9] Hadassah Hebrew Univ Med Ctr, Dept Radiol, Jerusalem, Israel

[10] Max Planck Inst Biol Cybernet, Magnet Resonance Ctr, Tubingen, Germany

[11] NYU, Dept Chem, 100 Washington Sq East, New York, NY 10003 USA

[12] Univ Torino, Dept Mol Biotechnol & Hlth Sci, Via Nizza 52, Turin, Italy

[13] Duke Univ, Dept Chem, Durham, NC 27708 USA

[14] Duke Univ, Dept Phys, Durham, NC 27708 USA

[15] Vanderbilt Univ, Inst Imaging Sci VUIIS, Dept Radiol & Radiol Sci, 1161 21st Ave South,MCN AA-1105, Nashville, TN 37027 USA

[16] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA

[17] Univ Texas MD Anderson Canc Ctr, Dept Canc Syst Imaging, Houston, TX 77030 USA

[18] Russian Acad Sci, Leninskiy Prospekt 14, Moscow 119991, Russia

[19] Wayne State Univ, Dept Chem, Karmanos Canc Inst, Detroit, MI 48202 USA

[20] Wayne State Univ, Integrat Biosci Ibio, Detroit, MI 48202 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 35期

基金：

俄罗斯科学基金会; 美国国家卫生研究院; 美国国家科学基金会;

关键词：

hyperpolarization; magnetic resonance imaging; NMR spectroscopy; parahydrogen; HYDROGEN-INDUCED POLARIZATION; NMR SIGNAL AMPLIFICATION; SABRE-DERIVED HYPERPOLARIZATION; REVERSIBLE EXCHANGE CATALYSIS; METAL-SUPPORT INTERACTIONS; SPIN-LATTICE-RELAXATION; NUCLEAR SINGLET-STATE; TO-NOISE RATIO; MAGNETIC-RESONANCE; IN-VIVO;

D O I：

10.1002/anie.201711842

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field. Hyperpolarization methods seek other means to increase the polarization and thus the MR signal. A unique source of pure spin order is the entangled singlet spin state of dihydrogen, parahydrogen (pH(2)), which is inherently stable and long-lived. When brought into contact with another molecule, this spin order on demand allows the MR signal to be enhanced by several orders of magnitude. Considerable progress has been made in the past decade in the area of pH(2)-based hyperpolarization techniques for biomedical applications. It is the goal of this Review to provide a selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications.

引用

页码：11140 / 11162

页数：23

共 273 条

[61] Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange [J].