Sinusoidal CD30+diffuse large B-cell lymphoma can masquerade as anaplastic large cell lymphoma in pediatric posttransplant lymphoproliferative disorders

被引：4
|
作者：
Bhatt, Neel S. [1 ]
Kelly, Michael E. [1 ]
Batdorf, Bjorn [2 ]
Gheorghe, Gabriela [2 ]
机构：
[1] Med Coll Wisconsin, Dept Pediat Hematol Oncol BMT, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Childrens Hosp Wisconsin, Dept Pathol, 9000 West Wisconsin Ave, Milwaukee, WI 53226 USA
来源：
PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 08期
关键词：
diffuse large B-cell lymphoma; posttransplant lymphoproliferative disorder; solid organ transplantation; CHEMOTHERAPY; RITUXIMAB; DISEASE;
D O I：
10.1002/pbc.26403
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Posttransplant lymphoproliferative disorder (PTLD) is a known complication of solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is frequently seen in this setting. However, CD30+ DLBCL with sinusoidal pattern of involvement has not been reported in pediatric PTLD. We are reporting a 9-year-old female child presented with diffuse lymphadenopathy postheart transplantation. The pattern of involvement was suggestive of anaplastic large cell lymphoma, but the malignant cells were positive for B-cell markers and negative for anaplastic lymphoma kinase. The patient was treated aggressively with multiagent chemotherapy and rituximab. Accurate diagnosis in PTLD is paramount in making management decisions.
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页数：3
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