Potential of Excipient Emulsions for Improving Quercetin Bioaccessibility and Antioxidant Activity: An in Vitro Study

被引：55
作者：
Chen, Xing [1 ]
Zou, Liqiang [1 ]
Liu, Wei [1 ]
McClements, David Julian [2 ,3 ]
机构：
[1] Nanchang Univ, State Key Lab Food Sci & Technol, 235 Nanjing East Rd, Nanchang 330047, Jiangxi, Peoples R China
[2] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA
[3] King Abdulaziz Univ, Fac Sci, Dept Biochem, POB 80203, Jeddah 21589, Saudi Arabia
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2016年 / 64卷 / 18期
基金：
中国国家自然科学基金;
关键词：
quercetin; bioavailability; excipient emulsions; in vitro digestion; bioaccessibility; plasma antioxidant power; DELIVERY-SYSTEMS; NUTRACEUTICAL BIOAVAILABILITY; ORAL BIOAVAILABILITY; ALPHA-TOCOPHEROL; HEALTHY-SUBJECTS; CARRIER OIL; DIGESTION; SOLUBILITY; ABSORPTION; STABILITY;
D O I：
10.1021/acs.jafc.6b01056
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The potential for excipient emulsions to enhance the bioaccessibility and antioxidant activity of quercetin was determined in this study. Oil-in-water excipient emulsions containing two levels (4 or 10%) of small lipid droplets (d < 250 nm) were prepared from a long-chain triglyceride (corn oil). The solubilization of quercetin by the excipient emulsions was faster than by bulk corn oil or bulk water, and the solubilization rate was higher at 100 degrees C than at 30 degrees C. The bioaccessibility of quercetin samples was determined using an in vitro gastrointestinal model, and the bioactivity of quercetin was determined using a rat feeding study. The excipient emulsions were more effective at enhancing quercetin bioaccessibility and rat plasma antioxidant activity than either bulk oil or bulk water. This effect was attributed to the rapid digestion of the long chain triglycerides when they were in an emulsified form, which led to the rapid production of mixed micelles capable of solubilizing, protecting, and transporting quercetin.
引用
收藏
页码：3653 / 3660
页数：8
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