Three types of muscles express three sodium-calcium exchanger isoforms

被引：8
作者：
Levitsky, Dmitri O. [1 ]
机构：
[1] Univ Nantes, Fac Sci & Tech, CNRS UMR 6204, F-44322 Nantes 3, France
来源：
SODIUM-CALCIUM EXCHANGE AND THE PLASMA MEMBRANE CA2+-ATPASE IN CELL FUNCTION: FIFTH INTERNATIONAL CONFERENCE | 2007年 / 1099卷
关键词：
sodium-calcium exchanger isoforms; skeletal muscle; smooth muscle; NCX1; NCX2; NCX3; development; calcium;
D O I：
10.1196/annals.1387.063
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The sodium-calcium exchanger (NCX) of plasma membrane is expressed in any animal cell. The specific role of its three isoforms (NCX1-3) is not yet established. Their levels vary considerably during murine postnatal development. In particular, in skeletal muscle, NCX1 expression decreases gradually upon aging while reciprocal changes take place for NCX3. NCX2 expression is restricted to brain and smooth muscles. The data on SDS-gel mobility shifts indicate that all three isoforms undergo Ca2+ -dependent conformational changes, and that an exchanger regulatory Ca2+ -binding domain interacts directly with mutually exclusive exons A and B inducing two different NCX1 conformations.
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收藏
页码：221 / 225
页数：5
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