Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes: the predictive value of anti-Mullerian hormone

被引：41
作者：
Ramezanali, Fariba [1 ]
Ashrafi, Mahnaz [1 ,2 ]
Hemat, Mandana [1 ]
Arabipoor, Arezoo [1 ]
Jalali, Samaneh [1 ]
Moini, Ashraf [1 ,3 ,4 ]
机构：
[1] ACECR, Royan Inst Reprod Biomed, Dept Endocrinol & Female Infertil, Reprod Biomed Res Ctr, Tehran, Iran
[2] Iran Univ Med Sci, Dept Obstet & Gynecol, Fac Med, Tehran, Iran
[3] Univ Tehran Med Sci, Roointan Arash Womens Hlth Res & Educ Hosp, Dept Gynecol & Obstet, Tehran, Iran
[4] Univ Tehran Med Sci, Vali E Asr Reprod Hlth Res Ctr, Tehran, Iran
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2016年 / 32卷 / 05期
关键词：
anti-Mullerian hormone; assisted reproductive technology outcome; luteinizing hormone/follicle-stimulating hormone ratio; phenotypes; polycystic ovary syndrome; IN-VITRO FERTILIZATION; FOLLICLE-STIMULATING-HORMONE; LUTEINIZING-HORMONE; LIVE BIRTH; DIAGNOSIS; PREGNANCY; BASAL; PCOS; CYCLES; COUNT;
D O I：
10.1016/j.rbmo.2016.01.010
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
This cross-sectional study aimed to evaluate IVF/intracytoplasmic sperm injection (ICSI) outcomes in different polycystic ovary syndrome (PCOS) phenotypes (A, B, C and D) compared with a control group and the predictive values of serum anti-Mullerian hormone (AMH) in PCOS phenotypes for main outcomes. This study evaluated 386 PCOS women and 350 patients with male factor infertility. Women with phenotypes A and C had significantly higher concentrations of AMH than those with phenotype B (P < 0.001). Clinical pregnancy rate (CPR) in the phenotype D group (53.3%) was higher than other groups (32.5%, 26.4% and 36.8%, respectively, in phenotypes A, B and C), but not to a significant level. Multivariable regression analysis, after adjusting for women's age and body mass index, revealed that PCOS phenotypes A and B were associated with a decreased CPR compared with the control group (odds ratio [OR]: 0.46, confidence interval [CI]: 0.26-0.8, P = 0.007 and OR: 0.34, CI: 0.18-0.62, P = 0.001, respectively). It seems a combination of hyperandrogenism and chronic anovulation is associated with a negative impact on the CPR in these patients. These results demonstrated that AMH concentration is related to PCO morphology but not predictive for CPR and live birth rate. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：503 / 512
页数：10
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