Memory-type ST2+CD4+T cells participate in the steroid-resistant pathology of eosinophilic pneumonia

被引：24

作者：

Mato, Naoko ^{[1
,2
]}

Hirahara, Kiyoshi ^{[2
]}

Ichikawa, Tomomi ^{[2
]}

Kumagai, Jin ^{[2
]}

Nakayama, Masayuki ^{[1
]}

Yamasawa, Hideaki ^{[1
]}

Bando, Masashi ^{[1
]}

Hagiwara, Koichi ^{[1
]}

Sugiyama, Yukihiko ^{[1
,3
]}

Nakayama, Toshinori ^{[2
]}

机构：

[1] Jichi Med Univ, Dept Internal Med, Div Pulm Med, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290434, Japan

[2] Chiba Univ, Grad Sch Med, Dept Immunol, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan

[3] Nerima Hikarigaoka Hosp, Dept Resp Med, Tokyo, Japan

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

INNATE LYMPHOID-CELLS; GENOME-WIDE ASSOCIATION; AIRWAY HYPERRESPONSIVENESS; ADIPOSE-TISSUE; INTERLEUKIN; 33; IL-33; INFLAMMATION; CYTOKINE; ABSENCE; ASTHMA;

D O I：

10.1038/s41598-017-06962-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The lung develops an unique epithelial barrier system to protect host from continuous invasion of various harmful particles. Interleukin (IL-)33 released from epithelial cells in the lung drives the type 2 immune response by activating ST2-expressed immune cells in various allergic diseases. However, the involvement of memory-type ST2(+)CD4(+)T cells in such lung inflammation remains unclear. Here we demonstrated that intratracheal administration of IL-33 resulted in the substantial increase of numbers of tissue-resident memory-type ST2(+)CD4(+)T cells in the lung. Following enhanced production of IL-5 and IL-13, eosinophilic lung inflammation sequentially developed. IL-33-mediated eosinophilic lung inflammation was not fully developed in T cell-deficient Foxn1(nu) mice and NSG mice. Dexamethasone treatment showed limited effects on both the cell number and function of memory-type ST2(+)CD4(+)T cells. Thus our study provides novel insight into the pathogenesis of eosinophilic lung disease, showing that memory-type ST2(+)CD4(+)T cells are involved in IL-33-induced eosinophilic inflammation and elicited steroid-resistance.

引用

页数：12

共 44 条

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