Is the question of phenobarbital as potential liver cancer risk factor for humans really resolved?

被引:23
作者
Braeuning, Albert [1 ,2 ]
Schwarz, Michael [2 ]
机构
[1] Fed Inst Risk Assessment, Dept Food Safety, Max Dohrn Str 8-10, D-10589 Berlin, Germany
[2] Univ Tubingen, Dept Toxicol, Wilhelmstr 56, D-72074 Tubingen, Germany
关键词
TUMOR PROMOTION; MICE;
D O I
10.1007/s00204-016-1712-0
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
引用
收藏
页码:1525 / 1526
页数:2
相关论文
共 7 条
[1]   Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of β-catenin-mutated mouse liver tumors [J].
Aydinlik, H ;
Nguyen, TD ;
Moennikes, O ;
Buchmann, A ;
Schwarz, M .
ONCOGENE, 2001, 20 (53) :7812-7816
[2]   Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice [J].
Braeuning, Albert ;
Gavrilov, Alina ;
Geissler, Miriam ;
Wenz, Christine ;
Colnot, Sabine ;
Templin, Markus F. ;
Metzger, Ute ;
Roemer, Michael ;
Zell, Andreas ;
Schwarz, Michael .
ARCHIVES OF TOXICOLOGY, 2016, 90 (06) :1481-1494
[3]   Phenobarbital-Mediated Tumor Promotion in Transgenic Mice with Humanized CAR and PXR [J].
Braeuning, Albert ;
Gavrilov, Alina ;
Brown, Susan ;
Wolf, C. Roland ;
Henderson, Colin J. ;
Schwarz, Michael .
TOXICOLOGICAL SCIENCES, 2014, 140 (02) :259-270
[4]   Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice [J].
Braeuning, Albert ;
Singh, Yasmin ;
Rignall, Benjamin ;
Buchmann, Albrecht ;
Hammad, Seddik ;
Othman, Amnah ;
von Recklinghausen, Iris ;
Godoy, Patricio ;
Hoehme, Stefan ;
Drasdo, Dirk ;
Hengstler, Jan G. ;
Schwarz, Michael .
HISTOCHEMISTRY AND CELL BIOLOGY, 2010, 134 (05) :469-481
[5]  
*IARC, 2001, IARC MON SOM THYR AG, P161
[6]   Phenotype of single hepatocytes expressing an activated version of β-catenin in liver of transgenic mice [J].
Schreiber, Sandra ;
Rignall, Benjamin ;
Braeuning, Albert ;
Marx-Stoelting, Philip ;
Ott, Thomas ;
Buchmann, Albrecht ;
Hammad, Seddik ;
Hengstler, Jan G. ;
Schwarz, Michael ;
Koehle, Christoph .
JOURNAL OF MOLECULAR HISTOLOGY, 2011, 42 (05) :393-400
[7]   Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets [J].
Schulze, Kornelius ;
Imbeaud, Sandrine ;
Letouze, Eric ;
Alexandrov, Ludmil B. ;
Calderaro, Julien ;
Rebouissou, Sandra ;
Couchy, Gabrielle ;
Meiller, Clement ;
Shinde, Jayendra ;
Soysouvanh, Frederic ;
Calatayud, Anna-Line ;
Pinyol, Roser ;
Pelletier, Laura ;
Balabaud, Charles ;
Laurent, Alexis ;
Blanc, Jean-Frederic ;
Mazzaferro, Vincenzo ;
Calvo, Fabien ;
Villanueva, Augusto ;
Nault, Jean-Charles ;
Bioulac-Sage, Paulette ;
Stratton, Michael R. ;
Llovet, Josep M. ;
Zucman-Rossi, Jessica .
NATURE GENETICS, 2015, 47 (05) :505-U106