Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation

被引：156

作者：

Meyer, Urs ^{[1
,2
,3
]}

机构：

[1] Univ Zurich Vetsuisse, Inst Pharmacol & Toxicol, Zurich, Switzerland

[2] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

[3] Swiss Fed Inst Technol, Zurich, Switzerland

来源：

TRENDS IN NEUROSCIENCES | 2019年 / 42卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

PRENATAL EXPOSURE; SPECTRUM DISORDERS; BRAIN-DEVELOPMENT; FETAL EXPOSURE; INFECTION; PREGNANCY; SCHIZOPHRENIA; AUTISM; RISK; STRESS;

D O I：

10.1016/j.tins.2019.08.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Maternal immune activation (MIA), be it triggered by infectious or noninfectious stimuli, is implicated in various psychiatric and neurological disorders with developmental etiologies. Its consequences on the offspring's mental health are heterogeneous and influenced by a number of factors shaping the specificity and/or severity of pathological outcomes. There is also a substantial degree of resilience to MIA, which determines the extent to which offspring are protected from developing neurodevelopmental sequelae. This review provides a synopsis of the plausible sources that account for the heterogeneous outcomes of MIA and discusses key factors that are critical for establishing neurodevelopmental resilience and susceptibility to this early-life adversity.

引用

页码：793 / 806

页数：14

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