Chiral drugs related to guaifenesin: synthesis and phase properties of methocarbamol and mephenoxalone

被引：30

作者：

Bredikhin, Alexander A. ^{[1
]}

Bredikhina, Zemfira A. ^{[1
]}

Zakharychev, Dmitry V. ^{[1
]}

Pashagin, Alexander V. ^{[1
]}

机构：

[1] Russian Acad Sci, AE Arbuzov Organ & Phys Chem Inst, Kazan 420088, Russia

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 10期

关键词：

D O I：

10.1016/j.tetasy.2007.05.019

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The muscle relaxant methocarbamol 2 and tranquilizer mephenoxalone 3, as well as intermediate cyclic carbonate 4, have been prepared in enantiopure form by starting from enantiopure guaifenesin 1 easily available by an entrainment resolution procedure. Thermal investigations reveal that 2 is probably a conglomerate forming substance, 3 forms a stable racemic compound, and 4 occupies an intermediate position. The enantiomeric excess of a binary phase eutectic point for these substances comprises 0%, 85%, and 10%, respectively. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1239 / 1244

页数：6

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