Organocatalytic Enantioselective Synthesis of 1,4-Dihydropyridines

被引：34

作者：

Auria-Luna, Fernando ^{[1
]}

Marques-Lopez, Eugenia ^{[1
]}

Herrera, Raquel P. ^{[1
]}

机构：

[1] Univ Zaragoza, CSIC, ISQCH, Lab Organocatalisis Asimetr,Dept Quim Organ, C Pedro Cerbuna 12, E-50009 Zaragoza, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 13期

关键词：

aminocatalysis; BINOL-derived phosphoric acids; 1,4-dihydropyridines; 1,4-DHPs; organocatalysis; (thio) ureas; AXIALLY CHIRAL BISPHOSPHORYLIMIDES; POT MULTICOMPONENT REACTIONS; ASYMMETRIC-SYNTHESIS; CALCIUM-CHANNEL; 1,3-DICARBONYL COMPOUNDS; BRONSTED ACIDS; SUBSTITUTED 1,4-DIHYDROPYRIDINES; FUNCTIONALIZED DIHYDROPYRIDINES; MEDICINAL CHEMISTRY; EFFICIENT SYNTHESIS;

D O I：

10.1002/adsc.201700300

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This review aims to bring light upon a very interesting group of compounds, the 1,4-dihydropyridines (1,4-DHPs). These structures are well-known pharmacophores, used for many years to treat cardiovascular diseases because of their activity as calcium channel blockers. In addition, their potential as drugs to treat other affections has been recently exposed. The racemic synthesis of 1,4-DHPs has been well studied, while the asymmetric approaches are mainly based on the use of chiral auxiliaries or chiral resolutions. However, there are scarce examples regarding enantioselective organocatalytic methods. Herein, we will summarize the existing examples in this field of research.

引用

页码：2161 / 2175

页数：15

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