Filter-less fluorescence sensor with high separation ability achieved by the suppression of forward-scattered light in silicon

被引:8
作者
Choi, Yong Joon [1 ]
Takahashi, Kazuhiro [1 ]
Matsuda, Motoharu [1 ]
Hizawa, Takeshi [1 ]
Moriwaki, Yu [1 ]
Dasai, Fumihiro [1 ]
Kimura, Yasuyuki [1 ]
Akita, Ippei [1 ]
Iwata, Tatsuya [1 ]
Ishida, Makoto [1 ]
Sawada, Kazuaki [1 ]
机构
[1] Toyohashi Univ Technol, Dept Elect & Elect Informat Engn, Toyohashi, Aichi 4418580, Japan
基金
日本科学技术振兴机构; 日本学术振兴会;
关键词
DNA ANALYSIS; SYSTEM; DETECTOR; ARRAYS;
D O I
10.7567/JJAP.55.04EM10
中图分类号
O59 [应用物理学];
学科分类号
摘要
The improvement of a filter-less fluorescence sensor, by suppressing forward scattering in silicon by surface planarization is presented. A fluorescence microscope has been widely used in biochemical fields. However, it is difficult to miniaturize because optical filters and other parts are necessary. We previously developed a filter-less fluorescence sensor. The separation ability of excitation light and fluorescence in the previous device was 550: 1. It is necessary to improve the separation ability. This study focuses on the suppression of forward-scattered incident light in silicon, through the enhanced surface planarization of polysilicon, which is the gate electrode material. The separation ability of the filter-less fluorescence sensor was increased from 550: 1 to 1250: 1 by the suppression of forward-scattered light. (C) 2016 The Japan Society of Applied Physics
引用
收藏
页数:6
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共 28 条
[1]   Microfluidic integration on detector arrays for absorption and fluorescence micro-spectrometers [J].
Adams, ML ;
Enzelberger, M ;
Quake, S ;
Scherer, A .
SENSORS AND ACTUATORS A-PHYSICAL, 2003, 104 (01) :25-31
[2]   Real-time quantitative LAMP (loop-mediated isothermal amplification of DNA) as a simple method for monitoring ammonia-oxidizing bacteria [J].
Aoi, Yoshiteru ;
Hosogai, Mariko ;
Tsuneda, Satoshi .
JOURNAL OF BIOTECHNOLOGY, 2006, 125 (04) :484-491
[4]   An integrated nanoliter DNA analysis device [J].
Burns, MA ;
Johnson, BN ;
Brahmasandra, SN ;
Handique, K ;
Webster, JR ;
Krishnan, M ;
Sammarco, TS ;
Man, PM ;
Jones, D ;
Heldsinger, D ;
Mastrangelo, CH ;
Burke, DT .
SCIENCE, 1998, 282 (5388) :484-487
[5]   An integrated fluorescence detection system in poly(dimethylsiloxane) for microfluidic applications [J].
Chabinyc, ML ;
Chiu, DT ;
McDonald, JC ;
Stroock, AD ;
Christian, JF ;
Karger, AM ;
Whitesides, GM .
ANALYTICAL CHEMISTRY, 2001, 73 (18) :4491-4498
[6]   Optical filtering technologies for integrated fluorescence sensors [J].
Dandin, Marc ;
Abshire, Pamela ;
Smela, Elisabeth .
LAB ON A CHIP, 2007, 7 (08) :955-977
[7]   Low Light CMOS Contact Imager with an Integrated Poly-Acrylic Emission Filter for Fluorescence Detection [J].
Dattner, Yonathan ;
Yadid-Pecht, Orly .
SENSORS, 2010, 10 (05) :5014-5027
[8]   Sensitivity and accuracy of quantitative real-time polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions [J].
Deprez, RHL ;
Fijnvandraat, AC ;
Ruijter, JM ;
Moorman, AFM .
ANALYTICAL BIOCHEMISTRY, 2002, 307 (01) :63-69
[9]   Colorimetric porous photonic bandgap sensors with integrated CMOS color detectors [J].
Fang, Xiaoyue ;
Hsiao, Vincent K. S. ;
Chodavarapu, Vamsy P. ;
Titus, Albert H. ;
Cartwright, Alexander N. .
IEEE SENSORS JOURNAL, 2006, 6 (03) :661-667
[10]   Total integrated scatter from surfaces with arbitrary roughness, correlation widths, and incident angles [J].
Harvey, James E. ;
Schroeder, Sven ;
Choi, Narak ;
Duparre, Angela .
OPTICAL ENGINEERING, 2012, 51 (01)