Antiageing activities of water-soluble chitosan from Clanis bilineata larvae

被引：17
|
作者：
Wu, Shengjun [1 ,2 ,3 ]
Lu, Mingsheng [1 ,2 ,3 ]
Wang, Shujun [1 ,2 ,3 ]
机构：
[1] Huaihai Inst Technol, Sch Marine Life & Fisheries, 59 Cangwu Rd, Xinpu 222005, Peoples R China
[2] Huaihai Inst Technol, Coinnovat Ctr Jiangsu Marine Bioind Technol, Lianyungang 222005, Peoples R China
[3] Huaihai Inst Technol, Jiangsu Marine Resources Dev Res Inst, Lianyungang 222005, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2017年 / 102卷
基金：
中国国家自然科学基金;
关键词：
Clanis bilineata; Antioxidant activity; Antiageing activity; ANTIOXIDANT ACTIVITIES; ANTIAGING ACTIVITIES; EDIBLE INSECT; IN-VIVO; PHYSICOCHEMICAL CHARACTERIZATION; ANTIBACTERIAL ACTIVITY; HYPOLIPIDEMIC ACTIVITY; RESTING EGGS; CHITIN; LEPIDOPTERA;
D O I：
10.1016/j.ijbiomac.2017.04.038
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Water extracts were prepared using water-soluble chitosan from Clanis bilineata larva skin. This study also investigated antioxidant and antiageing activities of water-soluble chitosan. Water-soluble chitosan of Clanis bilineata larva skin (CBLSWSC) showed considerable scavenging activities on superoxide anion and hydroxyl radicals and reducing capacity. Different doses of CBLSWSC were intragastrically administered on a D-galactose-induced-aged mouse model over a period of six weeks. Intragastric CBLSWSC administration significantly increased activities of superoxide dismutase and glutathione peroxidase and inhibited formation of malondialdehyde in brains and sera of mice in a dose-dependent manner. Results suggest that CBLSWSC exhibits high antioxidant activity and can be developed as potential dietary supplement to retard ageing in humans. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：376 / 379
页数：4
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