Human papilloma virus type 16 infection and the early onset of cervical cancer

被引：11

作者：

Karube, A

Sasaki, M

Tanaka, H

Nakagome, O

Dahiya, R ^{[1
]}

Fujimoto, S

Tanaka, T

机构：

[1] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94121 USA

[2] Vet Affairs Med Ctr, San Francisco, CA 94121 USA

[3] Akita Univ, Sch Med, Dept Obstet & Gynecol, Akita 010, Japan

[4] Akita Univ, Sch Med, Dept Microbiol, Akita 010, Japan

[5] Tenshi Hosp, Lab Clin Genet, Caress Alliance Med Corp, Higashi Ku, Sapporo, Hokkaido 065, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 323卷 / 02期

关键词：

papilloma virus type 16; cervical cancer; early onset; age;

D O I：

10.1016/j.bbrc.2004.08.142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human papilloma viruses (HPV), particularly type 16, have been associated with cervical cancer. It has been noted that the average onset of cervical cancer is occurring in younger women coupled with a higher prevalence of cervical HPV infection. However, the correlation between HPV 16 infection and the early onset of cervical cancer is still unclear. We hypothesize that HPV infection is an indicator of early onset of cervical cancer. To test this hypothesis, cervical smears from 197 women were evaluated by the polymerase chain reaction for HPV 16. These data revealed that the HPV 16-positive women were significantly younger than the HPV 16-negative women. Moreover, the average age of HPV 16-positive women with CIN 3 or invasive cancer was significantly younger compared with the other groups. These data clearly suggest that HPV 16 infection is a significant risk factor for the progression for cervical cancer in a young population of women. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：621 / 624

页数：4

共 22 条

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