Radiation-induced Oral Mucositis

被引：300
作者：
Maria, Osama Muhammad [1 ,2 ,3 ]
Eliopoulos, Nicoletta [3 ,4 ]
Muanza, Thierry [1 ,2 ,3 ,5 ]
机构：
[1] McGill Univ, Expt Med Dept, Fac Med, Montreal, PQ, Canada
[2] McGill Univ, Jewish Gen Hosp, Radiat Oncol Dept, Montreal, PQ, Canada
[3] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada
[4] McGill Univ, Surg Dept, Fac Med, Montreal, PQ, Canada
[5] McGill Univ, Oncol Dept, Montreal, PQ, Canada
来源：
FRONTIERS IN ONCOLOGY | 2017年 / 7卷
关键词：
chemotherapy; oral mucositis; radiation; radiotherapy; normal tissue injury; pathobiology; mesenchymal stromal/stem cells; MANGANESE SUPEROXIDE-DISMUTASE; KERATINOCYTE GROWTH-FACTOR; COLONY-STIMULATING FACTOR; NECK-CANCER PATIENTS; RADIOTHERAPY-INDUCED MUCOSITIS; STEM-CELL TRANSPLANT; BONE-MARROW-TRANSPLANTATION; PLACEBO-CONTROLLED TRIAL; BLIND RANDOMIZED-TRIAL; HIGH-DOSE CHEMOTHERAPY;
D O I：
10.3389/fonc.2017.00089
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiation-induced oral mucositis (RIOM) is a major dose-limiting toxicity in head and neck cancer patients. It is a normal tissue injury caused by radiation/radiotherapy (RT), which has marked adverse effects on patient quality of life and cancer therapy continuity. It is a challenge for radiation oncologists since it leads to cancer therapy interruption, poor local tumor control, and changes in dose fractionation. RIOM occurs in 100% of altered fractionation radiotherapy head and neck cancer patients. In the United Sates, its economic cost was estimated to reach 17,000.00 USD per patient with head and neck cancers. This review will discuss RIOM definition, epidemiology, impact and side effects, pathogenesis, scoring scales, diagnosis, differential diagnosis, prevention, and treatment.
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页数：23
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