Using Chitosan or Chitosan Derivatives in Cancer Therapy

被引：53
作者：
Shakil, Md Salman [1 ,2 ]
Mahmud, Kazi Mustafa [3 ]
Sayem, Mohammad [2 ,4 ]
Niloy, Mahruba Sultana [3 ]
Halder, Sajal Kumar [3 ]
Hossen, Md. Sakib [2 ]
Uddin, Md. Forhad [3 ]
Hasan, Md. Ashraful [3 ]
机构：
[1] Univ Otago, Dept Pharmacol & Toxicol, Dunedin 9016, New Zealand
[2] Primeasia Univ, Dept Biochem, Dhaka 1213, Bangladesh
[3] Jahangirnagar Univ, Dept Biochem & Mol Biol, Dhaka 1342, Bangladesh
[4] Univ Dhaka, Dept Biochem & Mol Biol, Dhaka 1000, Bangladesh
来源：
POLYSACCHARIDES | 2021年 / 2卷 / 04期
关键词：
chitosan; chitosan derivatives; anticancer activities; gene and drug delivery; immunotherapy; GENE DELIVERY; IN-VITRO; DRUG-DELIVERY; NANOPARTICLE FORMULATION; ANTICANCER ACTIVITY; GOLD NANOMATERIALS; TRIMETHYL CHITOSAN; CONTROLLED-RELEASE; TARGETED DELIVERY; INDUCE APOPTOSIS;
D O I：
10.3390/polysaccharides2040048
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.
引用
收藏
页码：795 / 816
页数：22
相关论文
共 152 条
[1]   Biopolymer and Biomaterial Conjugated Iron Oxide Nanomaterials as Prostate Cancer Theranostic Agents: A Comprehensive Review [J].
Abu Rayhan, Md. ;
Hossen, Md. Sakib ;
Niloy, Mahruba Sultana ;
Bhuiyan, Mozammel Haque ;
Paul, Sudip ;
Shakil, Md. Salman .
SYMMETRY-BASEL, 2021, 13 (06)
[2]   Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action [J].
Adhikari, Hari Sharan ;
Yadav, Paras Nath .
INTERNATIONAL JOURNAL OF BIOMATERIALS, 2018, 2018
[3]   Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery [J].
Ahmed, Tarek A. ;
Aljaeid, Bader M. .
DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 10 :483-507
[4]   Chitosan Stabilized Gold-Folate-Poly(lactide-co-glycolide) Nanoplexes Facilitate Efficient Gene Delivery in Hepatic and Breast Cancer Cells [J].
Akinyelu, Jude ;
Singh, Moganavelli .
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2018, 18 (07) :4478-4486
[5]   Chitosan-Coated Flexible Liposomes Magnify the Anticancer Activity and Bioavailability of Docetaxel: Impact on Composition [J].
Alshraim, Mohammed O. ;
Sangi, Sibghatullah ;
Harisa, Gamaleldin I. ;
Alomrani, Abdullah H. ;
Yusuf, Osman ;
Badran, Mohamed M. .
MOLECULES, 2019, 24 (02) :1-14
[6]   Study on Different Molecular Weights of Chitosan as an Immobilization Matrix for a Glucose Biosensor [J].
Ang, Lee Fung ;
Por, Lip Yee ;
Yam, Mun Fei .
PLOS ONE, 2013, 8 (08)
[7]  
Attwood D, 2012, Surfactant systems: their chemistry, pharmacy and biology
[8]   Multifaceted Applications of Chitosan in Cancer Drug Delivery and Therapy [J].
Babu, Anish ;
Ramesh, Rajagopal .
MARINE DRUGS, 2017, 15 (04)
[9]  
Bakht MK, 2012, CURR CANCER DRUG TAR, V12, P998
[10]   Optimization of carboxymethyl chitosan synthesis using response surface methodology and desirability function [J].
Bukzem, Andrea L. ;
Signini, Roberta ;
dos Santos, Danilo M. ;
Liao, Luciano M. ;
Ascheri, Diego Palmiro R. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 85 :615-624
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