TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene

被引：58
作者：
Dex, Sarah [1 ]
Lin, Dasheng [1 ]
Shukunami, Chisa [2 ]
Docheva, Denitsa [1 ,3 ]
机构：
[1] LMU, Dept Surg, Expt Surg & Regenerat Med, Nussbaumstr 20, D-80336 Munich, Germany
[2] Hiroshima Univ, Dept Mol Biol & Biochem, Div Basic Life Sci, Inst Biomed & Hlth Sci, Hiroshima, Japan
[3] Med Univ Plovdiv, Dept Med Biol, Plovdiv, Bulgaria
来源：
GENE | 2016年 / 587卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Tenomodulin; BRICHOS; Tendon; Eye; Chordae tendineae cordis; Vasculature; Periodontal ligament; Knockout mice; Tendon stem/progenitor cells; Cell differentiation; Gene marker; Single nucleotide polymorphism; Obesity; Metabolic syndrome; MESENCHYMAL STEM-CELLS; ANTERIOR CRUCIATE LIGAMENT; TENDON STEM/PROGENITOR CELLS; FINNISH DIABETES PREVENTION; POTENTIAL ANGIOGENIC FACTOR; MARROW STROMAL CELLS; CHONDROMODULIN-I; BONE-MARROW; PROGENITOR CELLS; TENOCYTE DIFFERENTIATION;
D O I：
10.1016/j.gene.2016.04.051
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Tenomodulin (TNMD, Tnmd) is a gene highly expressed in tendon known to be important for tendon maturation with key implications for the residing tendon stem/progenitor cells as well as for the regulation of endothelial cell migration in chordae tendineae cordis in the heart and in experimental tumour models. This review aims at providing an encompassing overview of this gene and its protein. In addition, its known expression pattern as well as putative signalling pathways will be described. A chronological overview of the discovered functions of this gene in tendon and other tissues and cells is provided as well as its use as a tendon and ligament lineage marker is assessed in detail and discussed. Last, information about the possible connections between TNMD genomic mutations and mRNA expression to various diseases is delivered. Taken together this review offers a solid synopsis on the up-to-date information available about TNMD and aids at directing and focusing the future research to fully uncover the roles and implications of this interesting gene. (C) 2016 The Authors. Published by Elsevier B.V.
引用
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页码：1 / 17
页数：17
相关论文
共 159 条
[1]  
Al-Sadi Onays, 2011, Muscles Ligaments Tendons J, V1, P68
[2]   Loss of Tenomodulin Results in Reduced Self-Renewal and Augmented Senescence of Tendon Stem/Progenitor Cells [J].
Alberton, Paolo ;
Dex, Sarah ;
Popov, Cvetan ;
Shukunami, Chisa ;
Schieker, Matthias ;
Docheva, Denitsa .
STEM CELLS AND DEVELOPMENT, 2015, 24 (05) :597-609
[3]   Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis [J].
Alberton, Paolo ;
Popov, Cvetan ;
Praegert, Markus ;
Kohler, Julia ;
Shukunami, Chisa ;
Schieker, Matthias ;
Docheva, Denitsa .
STEM CELLS AND DEVELOPMENT, 2012, 21 (06) :846-858
[4]   Substance P Is a Mechanoresponsive, Autocrine Regulator of Human Tenocyte Proliferation [J].
Backman, Ludvig J. ;
Fong, Gloria ;
Andersson, Gustav ;
Scott, Alexander ;
Danielson, Patrik .
PLOS ONE, 2011, 6 (11)
[5]   MAMMALIAN SUBTILISINS - THE LONG-SOUGHT DIBASIC PROCESSING ENDOPROTEASES [J].
BARR, PJ .
CELL, 1991, 66 (01) :1-3
[6]  
Barsby T, 2014, TISSUE ENG PT A, V20, P2604, DOI [10.1089/ten.tea.2013.0457, 10.1089/ten.TEA.2013.0457]
[7]   Effect of Fiber Diameter and Alignment of Electrospun Polyurethane Meshes on Mesenchymal Progenitor Cells [J].
Bashur, Chris A. ;
Shaffer, Robyn D. ;
Dahlgren, Linda A. ;
Guelcher, Scott A. ;
Goldstein, Aaron S. .
TISSUE ENGINEERING PART A, 2009, 15 (09) :2435-2445
[8]   Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities [J].
Berasi, Stephen P. ;
Varadarajan, Usha ;
Archambault, Joanne ;
Cain, Michael ;
Souza, Tatyana A. ;
Abouzeid, Abe ;
Li, Jian ;
Brown, Christopher T. ;
Dorner, Andrew J. ;
Seeherman, Howard J. ;
Jelinsky, Scott A. .
GROWTH FACTORS, 2011, 29 (04) :128-139
[9]   Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche [J].
Bi, Yanming ;
Ehirchiou, Driss ;
Kilts, Tina M. ;
Inkson, Colette A. ;
Embree, Mildred C. ;
Sonoyama, Wataru ;
Li, Li ;
Leet, Arabella I. ;
Seo, Byoung-Moo ;
Zhang, Li ;
Shi, Songtao ;
Young, Marian F. .
NATURE MEDICINE, 2007, 13 (10) :1219-1227
[10]   Chondromodulin I is dispensable during enchondral ossification and eye development [J].
Brandau, O ;
Aszódi, A ;
Hunziker, EB ;
Neame, PJ ;
Vestweber, D ;
Fässler, R .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (18) :6627-6635
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