Hydrogen-Atom Transfer Catalysis for C-H Alkylation of Benzylic Fluorides

被引：7

作者：

Ohmatsu, Kohsuke ^{[1
,2
]}

Suzuki, Ryuhei ^{[1
,2
]}

Fujita, Hiroki ^{[1
,2
]}

Ooi, Takashi ^{[1
,2
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Inst Transformat BioMol WPIITbM, Nagoya, Aichi 4648601, Japan

[2] Nagoya Univ, Grad Sch Engn, Dept Mol & Macromol Chem, Nagoya, Aichi 4648601, Japan

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 17期

关键词：

LATE-STAGE FUNCTIONALIZATION; ACTIVATED ALKENES; DECATUNGSTATE ANION; BOND; PHOTOCATALYSIS; SUBSTITUTION;

D O I：

10.1021/acs.orglett.2c00817

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A photoinduced catalytic C(sp3)-H alkylation of benzylicfluorides is developed. The use of zwitterionic 1,2,3-triazolium amidate as ahydrogen-atom transfer catalyst is uniquely effective for promoting thistransformation. The combination of C-H alkylation with subsequentdisplacement of the C-F bond enables 1,1-difunctionalization of benzylicfluorides, providing rapid access to an array of functionalized molecularentities

引用

页码：3134 / 3137

页数：4

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