A Novel Scoring System Based on Fibrinogen and the Neutrophil-Lymphocyte Ratio as a Predictor of Chemotherapy Response and Prognosis in Patients with Advanced Gastric Cancer

被引：34

作者：

Arigami, Takaaki ^{[1
,2
]}

Uenosono, Yoshikazu ^{[2
]}

Ishigami, Sumiya ^{[1
]}

Okubo, Keishi ^{[1
]}

Kijima, Takashi ^{[1
]}

Yanagita, Shigehiro ^{[1
]}

Okumura, Hiroshi ^{[1
]}

Uchikado, Yasuto ^{[1
]}

Kijima, Yuko ^{[1
]}

Nakajo, Akihiro ^{[1
]}

Kurahara, Hiroshi ^{[1
]}

Kita, Yoshiaki ^{[1
]}

Mori, Shinichiro ^{[1
]}

Maemura, Kosei ^{[1
]}

Natsugoe, Shoji ^{[1
,2
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Digest Surg Breast & Thyroid Surg, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Mol Frontier Surg, Kagoshima 8908520, Japan

来源：

ONCOLOGY | 2016年 / 90卷 / 04期

关键词：

Fibrinogen; Neutrophil-lymphocyte ratio; Tumor response; Prognosis; Gastric cancer; SQUAMOUS-CELL CARCINOMA; ADVANCED RECTAL-CANCER; PREOPERATIVE CHEMORADIATION; PATHOLOGICAL RESPONSE; PLASMA-FIBRINOGEN; TUMOR-PROGRESSION; PLATELET COUNT; INFLAMMATION; CHEMORADIOTHERAPY; RESECTION;

D O I：

10.1159/000444494

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: We assessed the clinical applicability of the F-NLR score, which is based on fibrinogen (F) and the neutrophil-lymphocyte ratio (NLR), and the Glasgow Prognostic Score (GPS) to predict the therapeutic effects of chemotherapy or chemoradiotherapy on advanced gastric cancer and the prognoses of patients. Methods: Sixty-eight patients with advanced gastric cancer treated with first-line chemotherapy or chemoradiotherapy were classified into two groups based on tumor response. Furthermore, we categorized patients according to cutoff F-NLR scores of 2 [hyperfibrino-genemia (>400 mg/dl) and high NLR (>3.0)], 1 [one of these hematological abnormalities], and 0 [neither hyperfibrino-genemia nor high NLR]. Results: A total of 27 patients had progressive disease (PD) and 41 did not. The F-NLR scores were significantly higher in the PD than in the non-PD group (p = 0.003). Survival was significantly shorter for patients with high F-NLR scores and GPS (p = 0.0071 and p = 0.0065, respectively). Multivariate analysis selected the F-NLR score as an independent prognostic factor (p = 0.017). Conclusion: A novel grading system based on F-NLR scores, as well as the GPS, appears to have value as a clinical predictor of the therapeutic response of advanced gastric cancer to chemotherapy or chemoradiotherapy and the prognoses of patients. (C) 2016 S. Karger AG, Basel

引用

页码：186 / 192

页数：7

共 27 条

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