I2/TBPB Mediated Oxidative Reaction to Construct of Imidazo[1,5-α]pyridines under Metal-Free Conditions

被引：10

作者：

Qin, Mingda ^{[1
]}

Tian, Yuan ^{[1
]}

Guo, Xin ^{[1
]}

Yuan, Xinglong ^{[1
]}

Yang, Xueying ^{[1
]}

Chen, Baohua ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Lanzhou Univ, Zhongwei High Tech Inst, Zhongwei 755500, Ningxia, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 08期

基金：

中国国家自然科学基金;

关键词：

cycloaddition; heterocycles; high atom efficiency; metal-free catalysis; new reaction; SELECTIVE 3+2 CYCLOADDITION; PYRIDINE N-OXIDE; C-C BOND; EFFICIENT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; C(SP(3))-H BONDS; AMINATION; DERIVATIVES; 1,2,4-TRIAZOLES; HETEROCYCLES;

D O I：

10.1002/ajoc.201800285

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of imidazo[1,5-alpha]pyridines, one of the most important N-heterocyclic compounds due to their wide application, was reported in this study. Specifically, using I-2 as a non-metal catalyst and TBPB as an oxidant can efficiently facilitate the synthesis and avoid the use of a metal catalyst. The reaction between ethyl (E)-2-(benzylideneamino)acetate and pyridine represents an unprecedented 1,3-diolar cycloaddition in highly straightforward process with great value.

引用

页码：1591 / 1594

页数：4

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