I2/TBPB Mediated Oxidative Reaction to Construct of Imidazo[1,5-α]pyridines under Metal-Free Conditions

被引：10
|
作者：
Qin, Mingda [1 ]
Tian, Yuan [1 ]
Guo, Xin [1 ]
Yuan, Xinglong [1 ]
Yang, Xueying [1 ]
Chen, Baohua [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Zhongwei High Tech Inst, Zhongwei 755500, Ningxia, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 08期
基金：
中国国家自然科学基金;
关键词：
cycloaddition; heterocycles; high atom efficiency; metal-free catalysis; new reaction; SELECTIVE 3+2 CYCLOADDITION; PYRIDINE N-OXIDE; C-C BOND; EFFICIENT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; C(SP(3))-H BONDS; AMINATION; DERIVATIVES; 1,2,4-TRIAZOLES; HETEROCYCLES;
D O I：
10.1002/ajoc.201800285
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the synthesis of imidazo[1,5-alpha]pyridines, one of the most important N-heterocyclic compounds due to their wide application, was reported in this study. Specifically, using I-2 as a non-metal catalyst and TBPB as an oxidant can efficiently facilitate the synthesis and avoid the use of a metal catalyst. The reaction between ethyl (E)-2-(benzylideneamino)acetate and pyridine represents an unprecedented 1,3-diolar cycloaddition in highly straightforward process with great value.
引用
收藏
页码：1591 / 1594
页数：4
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