Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy

被引:19
作者
Bonomini, Mario [1 ]
Piscitani, Luca [2 ]
Di Liberato, Lorenzo [1 ]
Sirolli, Vittorio [1 ]
机构
[1] Univ G DAnnunzio, Chieti Pescara SS Annunziata Hosp, Nephrol & Dialysis Unit, Dept Med, Via Vestini, I-66013 Chieti, Italy
[2] San Salvatore Hosp, Nephrol & Dialysis Unit, Dept Med, Via Vetoio, I-67100 Laquila, Italy
关键词
biocompatibility; hemodialysis; membrane; biomaterial; protein adsorption; coagulation; platelet; surface modification; REGIONAL CITRATE ANTICOAGULATION; HEPARIN-GRAFTED MEMBRANE; OXIDATIVE STRESS; DIALYSIS MEMBRANES; COMPLEMENT; DIALYZER; MULTICENTER; ADSORPTION; DISEASE; COAGULATION;
D O I
10.3390/biomedicines10040844
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinant of the success and quality of hemodialysis therapy. Membrane properties influence solute removal and the interactions with blood components that define the membrane's biocompatibility. Bioincompatibility is considered a potential contributor to several uremic complications. Thus, the development of more biocompatible polymers used as hemodialyzer membrane is of utmost importance for improving results and clinical patient outcomes. Many different surface-modified membranes for hemodialysis have been manufactured over recent years by varying approaches in the attempt to minimize blood incompatibility. Their main characteristics and clinical results in hemodialysis patients were reviewed in the present article.
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页数:19
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