Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedical Applications

被引：1
作者：
de Almeida, Raimundo R. [1 ]
Gallo, Juan [2 ]
da Silva, Aierta C. C. [1 ]
da Silva, Ana K. O. [1 ]
Pessoa, Otilia D. L. [1 ]
Araujo, Tamara G. [3 ]
Leal, Luzia K. A. M. [3 ]
Fechine, Pierre B. A. [4 ]
Banobre-Lopez, Manuel [2 ]
Ricardo, Nagila M. P. S. [1 ]
机构：
[1] Univ Fed Ceara, Dept Quim Organ & Inorgan, Campus Pici, BR-60455760 Fortaleza, Ceara, Brazil
[2] Int Iberian Nanotechnol Lab, Adv Magnet Theranost Nanostruct Lab, Av Mestre Jose Veiga S-N, P-4715330 Braga, Portugal
[3] Univ Fed Ceara, Dept Farm, Rua Capitao Francisco Pedro 1210, BR-60430170 Fortaleza, Ceara, Brazil
[4] Univ Fed Ceara, Dept Quim Analit & Fis Quim, Campus Pici, BR-60444900 Fortaleza, Ceara, Brazil
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2017年 / 28卷 / 08期
关键词：
lipid mixture; magnetic hyperthermia; drug delivery; oncocalyxone-A; SOLID LIPID NANOPARTICLES; MAGNETIC NANOPARTICLES; IN-VITRO; DELIVERY-SYSTEM; HYPERTHERMIA; DRUG; FORMULATION; RELEASE; DESIGN;
D O I：
10.21577/0103-5053.20170007
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This work describes the development and characterization of triglyceride-based magnetic nanocomposites for application in magnetic hyperthermia and controlled drug delivery. The magnetic solid lipid nanocomposites (MSLN) constituted by mixtures of trilaurin-tricaprylin and trilaurin-tricaprin have been successfully obtained by emulsification-solvent evaporation method. The developed MSLNs were subjected to an external oscillating magnetic field and showed significant hyperthermia. The samples were exposed to frequencies of 688 and 869 kHz causing, respectively, a temperature increase of 15.5 and 22.7 degrees C (trilaurin-tricaprylin) and 17.3 and 26.1 degrees C (trilaurin-tricaprin). Also, in vitro assays in the absence of magnetic field showed that the triglyceride-based formulations were able first to encapsulate and then to sustained release an antitumoural hydrophobic drug. After 72 h of assay trilaurin-tricaprylin and trilaurin-tricaprin released 73 and 55% of their cargo, respectively. In addition, MSLN exhibited low in vitro cytotoxic activity against human neutrophils.
引用
收藏
页码：1547 / 1556
页数：10
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