INVESTIGATED THE SUPRAMOLECULAR INTERACTION OF TRAMADOL HYDROCHLORIDE WITH P-SULFONATED CALIX[4,6,8]ARENE

被引：4

作者：

Zhao, Qing-Hua ^{[1
]}

Chen, Cai-Ping ^{[1
]}

Pang, Tao-Tao ^{[1
]}

Du, Li-Ming ^{[1
]}

Li, Yan ^{[1
]}

Xie, Jian-Hong ^{[1
]}

Fu, Yun-Long ^{[1
]}

机构：

[1] Shanxi Normal Univ, Sch Chem & Mat Sci, Linfen 041004, Shanxi, Peoples R China

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2015年 / 60卷 / 04期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Tramadol hydrochloride; Spectrofluorometry; Supramolecular interaction; p-sulfonated calyx[n]arene; INCLUSION INTERACTION; O-DESMETHYLTRAMADOL; HPLC DETERMINATION; AMINO-ACIDS; COMPLEXATION; VALIDATION; PLASMA; IONS;

D O I：

10.4067/S0717-97072015000400007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, the interaction behavior of p-sulfonated calix[n]arene (SCnA) with tramadol hydrochloride was investigated by fluorescence spectra, H-1 NMR spectra, and theoretical calculations in aqueous solution. At the optimized conditions, the fluorescence intensity of tramadol hydrochloride showed positive correlation to the concentration of SCnA, which led to a validated, simple, and sensitive fluorescence quenching method for the determination of tramadol hydrochloride was established for the first time. Moreover, the interaction based on SCnA superstructure provided has promising potential for therapeutic monitoring and pharmacokinetics and clinical application

引用

页码：2659 / 2663

页数：5

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