Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes

被引：39

作者：

Kuranov, RV ^{[1
]}

Sapozhnikova, VV ^{[1
]}

Shakhova, HM ^{[1
]}

Gelikonov, VM ^{[1
]}

Zagainova, EV ^{[1
]}

Petrova, SA ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Appl Phys, Nizhnii Novgorod 603950, Russia

来源：

QUANTUM ELECTRONICS | 2002年 / 32卷 / 11期

关键词：

optical coherent tomography; cross-polarisation optical coherent tomography; fluorescence spectroscopy; aminolevulinic acid;

D O I：

10.1070/QE2002v032n11ABEH002334

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

A combined application of optical methods [optical coherent tomography (OCT), cross-polarisation optical coherent tomography, and fluorescence spectroscopy] is proposed for obtaining information on morphological and biochemical changes occurring in tissues in norm and pathology. It is shown that neoplastic and sear changes in esophagus can be distinguished using a combination of polarisation and standard OCT due to the difference between the depolarising properties of the tissues caused by the structural properties of collagenic fibres in stroma. It is shown that OCT combined with fluorescence spectroscopy with the use of 5-aminolevulinic acid is promising for determining the boundaries of carcinoma of the uterine cervix and vulva. It is found that the tumour boundary detected by optical methods coincides with the morphological boundary and extends beyond colposcopically determined boundary by about 2 mm.

引用

页码：993 / 998

页数：6

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