First total synthesis of (±)-prelunularin

被引：1

作者：

Comas, H ^{[1
]}

Pandolfi, E ^{[1
]}

机构：

[1] Univ Republica, Fac Quim, Dept Quim Organ, Montevideo, Uruguay

来源：

SYNTHESIS-STUTTGART | 2004年 / 15期

关键词：

tandem reactions; natural products; intramolecular cyclization;

D O I：

10.1055/s-2004-831240

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of (+/-)-prelunularin is described employing an intramolecular aldol addition/sulfinate elimination tandem reaction. Investigations on the mechanism of the one-pot cyclization reaction using time-dependent NMR spectroscopy suggested that the sulfinate elimination took place before the intramolecular ring-closing aldol addition.

引用

页码：2493 / 2498

页数：6

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