Effects of intranasal oxytocin on emotional face processing in women

被引：416

作者：

Domes, Gregor ^{[1
,2
]}

Lischke, Alexander ^{[2
]}

Berger, Christoph ^{[2
]}

Grossmann, Annette ^{[3
]}

Hauenstein, Karlheinz ^{[3
]}

Heinrichs, Markus ^{[1
]}

Herpertz, Sabine C. ^{[4
]}

机构：

[1] Univ Freiburg, Dept Psychol, D-79104 Freiburg, Germany

[2] Univ Rostock, Dept Psychiat & Psychotherapy, D-2500 Rostock 1, Germany

[3] Univ Rostock, Dept Radiol, D-2500 Rostock 1, Germany

[4] Heidelberg Univ, Dept Gen Psychiat, D-6900 Heidelberg, Germany

来源：

PSYCHONEUROENDOCRINOLOGY | 2010年 / 35卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

Oxytocin; Neuropeptides; Facial emotions; Women; Amygdala; Functional magnetic-resonance imaging; PITUITARY-ADRENAL AXIS; SEX-DIFFERENCES; SOCIAL COGNITION; NEURAL CIRCUITRY; MENSTRUAL-CYCLE; VASOPRESSIN; AMYGDALA; RESPONSES; ACTIVATION; BEHAVIOR;

D O I：

10.1016/j.psyneuen.2009.06.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity to social and emotional stimuli in healthy men. The present study aimed to investigate the effect of intranasally administered OXT on brain activity in response to social emotional stimuli of varying valence in women. In a functional magnetic-resonance imaging study, sixteen women were presented with fearful, angry, happy and neutral facial expressions after a single dose of 24 IU OXT or a placebo administration in a within-subject design. Group analysis revealed that the blood-oxygen-level-dependent (BOLD) signal was enhanced in the left amygdala, the fusiform gyrus and the superior temporal gyrus in response to fearful faces and in the inferior frontal gyrus in response to angry and happy faces following OXT treatment. This effect was independent of fixation pattern to specific sections of the facial stimuli as revealed by eye tracking and independent of basal plasma levels of OXT, estradiol, and progesterone. The results are at odds with the previously reported effects found in men. Future studies should include both sexes to determine a possible sexual dimorphism in the neural effects of OXT, considering gonadal steroids and OXT receptor affinity. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：83 / 93

页数：11

共 59 条

[1]

Adolphs Ralph, 2002, Behav Cogn Neurosci Rev, V1, P21, DOI 10.1177/1534582302001001003

[2] AMYGDALO-CORTICAL PROJECTIONS IN THE MONKEY (MACACA-FASCICULARIS) [J].