Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities

被引：137

作者：

Hosoi, Toru ^{[1
]}

Ozawa, Koichiro ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Pharmacotherapy, Grad Sch Biomed Sci, Minami Ku, Hiroshima 7348553, Japan

来源：

CLINICAL SCIENCE | 2010年 / 118卷 / 1-2期

关键词：

apoptosis; cancer; neurodegenerative disease; endoplasmic reticulum; obesity; stress response; unfolded protein response; UNFOLDED-PROTEIN RESPONSE; INITIATION-FACTOR; 2; GLUCOSE-REGULATED PROTEINS; VASCULAR ENDOTHELIAL-CELLS; INDUCED CHOP EXPRESSION; ER STRESS; TRANSCRIPTION FACTOR; DISULFIDE-ISOMERASE; LEPTIN RESISTANCE; ALPHA-SYNUCLEIN;

D O I：

10.1042/CS20080680

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Various stresses, which impair ER (endoplasmic reticulum) function, lead to an accumulation of unfolded or misfolded proteins. ER stress triggers many rescuer responses, including a UPR (unfolded protein response). Increasing evidence has suggested that ER stress is involved in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and cerebral ischaemic insults), cancer, obesity and diabetes. In the present review, we consider the importance of ER stress under pathological conditions in mammals. Furthermore, we discuss the therapeutic potential for treatment: targeting ER stress.

引用

页码：19 / 29

页数：11

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