Susceptibility to leprosy is linked to the human NRAMP1 gene

被引：211

作者：

Abel, L

Sánchez, FO

Oberti, J

Thuc, NV

Van Hoa, L

Lap, VD

Skamene, E

Lagrange, PH

Schurr, E

机构：

[1] Montreal Gen Hosp, Res Inst, McGill Ctr Study Host Resistance, Montreal, PQ H3G 1A4, Canada

[2] Hop La Pitie Salpetriere, INSERM, U436, Paris, France

[3] Hop St Louis, Dept Microbiol, Paris, France

[4] Inst Agron Med Montpellier, INSERM, U431, Montpellier, France

[5] McGill Univ, Dept Expt Med, Montreal, PQ H3A 2T5, Canada

[6] McGill Univ, Dept Biochem, Montreal, PQ H3A 2T5, Canada

[7] Dermatol Hosp, Ho Chi Minh City, Vietnam

来源：

JOURNAL OF INFECTIOUS DISEASES | 1998年 / 177卷 / 01期

关键词：

D O I：

10.1086/513830

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leprosy is a debilitating infectious disease of human skin and nerves, Genetic factors of the host play an important role in the manifestation of disease susceptibility, The human NRAMP1 gene is a leprosy susceptibility candidate locus since its murine homologue Nramp1 (formerly Lsh/Ity/Bcg) controls innate resistance to Mycobacterium lepraemurium. In this study, 168 members of 20 multiplex leprosy families were genotyped for NRAMP1 alleles and 4 closely linked polymorphic markers, Highly informative haplotypes overlapping the NRAMP1 gene were constructed, and the haplotype segregation into leprosy-affected offspring was analyzed. It was observed that the segregation of NRAMP1 haplotypes into affected siblings was significantly nonrandom, This finding is consistent with the hypothesis that NRAMP1 itself is a leprosy susceptibility locus.

引用

页码：133 / 145

页数：13

共 32 条

[1]

ABEL L, 1988, AM J HUM GENET, V42, P256

[2] COMPLEX SEGREGATION ANALYSIS OF LEPROSY IN SOUTHERN VIETNAM [J].

ABEL, L ;

LAP, VD ;

OBERTI, J ;

VANTHUC, N ;

VANCUA, V ;

GUILLOUDBATAILLE, M ;

SCHURR, E ;

LAGRANGE, PH .

GENETIC EPIDEMIOLOGY, 1995, 12 (01) :63-82

[3] NH2-TERMINAL SEQUENCE OF MACROPHAGE-EXPRESSED NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN (NRAMP) ENCODES A PROLINE/SERINE-RICH PUTATIVE SRC HOMOLOGY 3-BINDING DOMAIN [J].

BARTON, CH ;

WHITE, JK ;

ROACH, TIA ;

BLACKWELL, JM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (05) :1683-1687

[4] 27TH FORUM IN IMMUNOLOGY - THE MACROPHAGE RESISTANCE GENE LSH ITY BCG - INTRODUCTION [J].

BLACKWELL, JM .

RESEARCH IN IMMUNOLOGY, 1989, 140 (08) :767-769

[5] GENETIC-REGULATION OF LEISHMANIAL AND MYCOBACTERIAL INFECTIONS - THE LSH/ITY/BCG GENE STORY CONTINUES [J].

BLACKWELL, JM ;

BARTON, CH ;

WHITE, JK ;

ROACH, TIA ;

SHAW, MA ;

WHITEHEAD, SH ;

MOCK, BA ;

SEARLE, S ;

WILLIAMS, H ;

BAKER, AM .

IMMUNOLOGY LETTERS, 1994, 43 (1-2) :99-107

[6]

BUU NT, 1995, IMMUNOGENETICS, V42, P428

[7] NRAMP DEFINES A FAMILY OF MEMBRANE-PROTEINS [J].

CELLIER, M ;

PRIVE, G ;

BELOUCHI, A ;

KWAN, T ;

RODRIGUES, V ;

CHIA, W ;

GROS, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) :10089-10093

[8] HUMAN NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN - CDNA CLONING, CHROMOSOMAL MAPPING, GENOMIC ORGANIZATION, AND TISSUE-SPECIFIC EXPRESSION [J].

CELLIER, M ;

GOVONI, G ;

VIDAL, S ;

KWAN, T ;

GROULX, N ;

LIU, J ;

SANCHEZ, F ;

SKAMENE, E ;

SCHURR, E ;

GROS, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (05) :1741-1752

[9] LINKAGE DISEQUILIBRIUM MAPPING OF A TYPE-1 DIABETES SUSCEPTIBILITY GENE (IDDM7) TO CHROMOSOME 2Q31-Q33 [J].

COPEMAN, JB ;

CUCCA, F ;

HEARNE, CM ;

CORNALL, RJ ;

REED, PW ;

RONNINGEN, KS ;

UNDLIEN, DE ;

NISTICO, L ;

BUZZETTI, R ;

TOSI, R ;

POCIOT, F ;

NERUP, J ;

CORNELIS, F ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE GENETICS, 1995, 9 (01) :80-85

[10]

DEVRIES RRP, 1976, LANCET, V2, P1328

← 1 2 3 4 →