Regulation of serotonin receptor function in the nervous system by lipid rafts and adaptor proteins

被引：34

作者：

Bjork, Karl ^{[1
]}

Sjogren, Benita ^{[1
]}

Svenningsson, Per ^{[1
]}

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, Ctr Mol Med, Karolinska Univ Hosp L8 01, S-17176 Stockholm, Sweden

来源：

EXPERIMENTAL CELL RESEARCH | 2010年 / 316卷 / 08期

关键词：

Caveolin; GPCR; Scaffolding proteins; Ligand bias; HUMAN 5-HT7(A) RECEPTORS; BETA-ARRESTIN; 5-HT2C RECEPTORS; SPLICE VARIANT; PDZ PROTEINS; BINDING; CAVEOLIN-1; P11; PSD-95; LOCALIZATION;

D O I：

10.1016/j.yexcr.2010.02.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

5-HT is a phylogenetically conserved monoaminergic neurotransmitter which is crucial for a number of physiological processes and is dysregulated in several disease states including depression, anxiety and schizophrenia. 5-HT neurons in the central nervous system are localized in the raphe nuclei and project to a wide range of target areas. 5-HT exerts its functions through 14 subtypes of 5-HT receptors. The tertiary structures of seven transmembrane 5-HT receptors contain several important features, including cholesterol consensus motifs, prominent intracellular loops and free C-termini. Alterations of cholesterol levels affect binding of ligands to 5-HT receptors and cholesterol-enriched microdomains in the cell membrane, termed lipid rafts, regulate 5-HT receptor internalization and signaling. The intracellular loops and the C-termini of 5-HT receptors provide binding sites for interacting adaptor proteins. Adaptor proteins affect internalization, desensitization as well as G-protein dependent and independent signaling via 5-HT receptors. We will here briefly review recent progress on the role of lipid rafts and adaptor proteins in the regulation of localization, trafficking, signaling and ligand bias of 5-HT receptors. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1351 / 1356

页数：6

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