Decanoic acid functionalized chitosan: Synthesis, characterization, and evaluation as potential wound dressing material

被引:25
|
作者
Dang, Qifeng [1 ]
Zhang, Qianqian [1 ]
Liu, Chengsheng [1 ]
Yan, Jingquan [2 ]
Chang, Guozhu [1 ]
Xin, Ying [3 ]
Cheng, Xiaoyu [3 ]
Cao, Yachan [1 ]
Gao, Hong [1 ]
Liu, Yan [1 ]
机构
[1] Ocean Univ China, Coll Marine Life Sci, 5 Yushan Rd, Qingdao 266003, Peoples R China
[2] Ocean Univ China, Sch Med & Pharm, 5 Yushan Rd, Qingdao 266003, Peoples R China
[3] Qingdao Univ, Affiliated Hosp, 308 Ningxia Rd, Qingdao 266071, Peoples R China
关键词
Decanoic acid functionalized chitosan; Characterization; Biocompatibility; Wound healing; CHITIN; DERIVATIVES;
D O I
10.1016/j.ijbiomac.2019.08.083
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Skin wound dressing materials, which can accelerate wound healing and have the synthetic advantages of simplicity, environmental safety, and resource abundance, are becoming a hot topic of research now. Following such a research trend, we prepared novel decanoic acid functionalized chitosan (CSDA) with good solubility by acylation via a facile one-step method. FTIR, H-1 NMR, and UV-Vis results demonstrated that alkyl chains were successfully grafted onto C2 positions of chitosan (CS) skeleton through acylation. XRD patterns implied that the crystallinity of CSDA greatly declined due to the introduction of alkylmoieties, favorable for improving water solubility. Conductometric titration results showed that the degrees of substitution of CSDA, CSDA1, and CSDA2 were 41.42, 26.12, and 23.17%, respectively. MTT assay and hemolysis experiments illustrated that all the CSDA amples tested in this work possessed good hemocompatibility (hemolysis rate < 2%) and excellent cytocompatibility (relative cell viability >75%) toward L929 cells. Moreover, CSDA-soaked gauze dressings and full-thickness excisional wound models were employed to estimate the feasibility of CSDA as wound dressing material, and the results displayed that CSDA with the degree of substitution of 41.42% could enhance the wound healing rate to 100% on day 16. Altogether, CSDA might be potential material used as wound dressing. (c) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码:1046 / 1053
页数:8
相关论文
共 50 条
  • [11] EGF loaded chitosan sponges as wound dressing material
    Denkbas, EB
    Öztürk, E
    Özdemir, N
    Keçeci, K
    Ergun, MA
    JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2003, 18 (03) : 177 - 190
  • [12] Preparation and characterization of ciprofloxacin-loaded alginate/chitosan sponge as a wound dressing material
    Ozturk, Eylem
    Agalar, Cartan
    Kececi, Kaan
    Denkbas, Emir B.
    JOURNAL OF APPLIED POLYMER SCIENCE, 2006, 101 (03) : 1602 - 1609
  • [13] Evaluation of chitosan nano dressing for wound healing: Characterization, in vitro and in vivo studies
    Archana, D.
    Dutta, Joydeep
    Dutta, P. K.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 57 : 193 - 203
  • [14] Characterization and in vitro evaluation of chitosan/konjac glucomannan bilayer film as a wound dressing
    Gomes Neto, Reginaldo Jose
    Genevro, Giovana Maria
    Paulo, Leticia de Almeida
    Lopes, Patricia Santos
    de Moraes, Mariana Agostini
    Beppu, Marisa Masumi
    CARBOHYDRATE POLYMERS, 2019, 212 : 59 - 66
  • [15] Evaluation of chitosan/γ-poly(glutamic acid) polyelectrolyte complex for wound dressing materials
    Tsao, Ching Ting
    Chang, Chih Hao
    Lin, Yu Yung
    Wu, Ming Fung
    Wang, Jaw Lin
    Young, Tai Horng
    Han, Jin Lin
    Hsieh, Kuo Haung
    CARBOHYDRATE POLYMERS, 2011, 84 (02) : 812 - 819
  • [16] In vivo evaluation of chitosan-PVP-titanium dioxide nanocomposite as wound dressing material
    Archana, D.
    Singh, Brijesh K.
    Dutta, Joydeep
    Dutta, P. K.
    CARBOHYDRATE POLYMERS, 2013, 95 (01) : 530 - 539
  • [17] Synthesis and characterization of nanofiber of gelatin, polyvinyl alcohol, and chitosan for wound dressing application
    Aliagha, Padideh
    Amiri, Sahar
    Ghiass, Majid
    JOURNAL OF THE TEXTILE INSTITUTE, 2024, 115 (05) : 703 - 712
  • [18] Preparation and characterization of antibacterial polyvinyl alcohol/chitosan sponge and potential applied for wound dressing
    Fan, Yao
    Lu, Qiaohui
    Liang, Wencheng
    Wang, Youchang
    Zhou, Yan
    Lang, Meidong
    EUROPEAN POLYMER JOURNAL, 2021, 157
  • [19] Chitosan/calcium phosphate-nanoflakes-based biomaterial: a potential hemostatic wound dressing material
    A. Mohamed Akram
    Rishabh Anand Omar
    Mohammad Ashfaq
    Polymer Bulletin, 2023, 80 : 5071 - 5086
  • [20] Chitosan/calcium phosphate-nanoflakes-based biomaterial: a potential hemostatic wound dressing material
    Akram, A. Mohamed
    Omar, Rishabh Anand
    Ashfaq, Mohammad
    POLYMER BULLETIN, 2023, 80 (05) : 5071 - 5086