Influence of pore size and surface area of mesoporous silica materilas (MCM-41 and KIT-6) on the drug loading and release

Mesoporous silica KIT-6 and MCM-41 with different pore sizes has been prepared through the sol-gel and hydrothermal method, respectively. The synthesized mesoporous materials were modified by a chemical modification using 3-aminopropyl triethoxysilane (APTES) to obtain KIT-6-NH2 and MCM-41-NH2 as drug delivery carriers. The mesostructure properties was fully characterized by scanning electron microscope (SEM), N-2 sorption isotherm, Fourier transform infrared (FT-IR), X-ray diffraction (XRD). Loading of resveratrol (RSV) drug as a model into synthesized mesoporous carriers and amine functionalized forms were studied using thermogravimetric analysis (TGA) and UV-visible spectroscopy (UV-Vis). The loading uptake and release behavior of RSV was highly dependent on the textural properties (such as pore size and surface area) of mesoporous silica and modified carriers. The release of drugs was carefully studied in different pH. The effect of the synthesized carriers and RSV@mesoporous drug carriers on MCF-7 human breast cancer cell line viability was evaluated. Both carriers alone revealed no toxicity to MCF-7 cancer cells. But, RSV@carriers or RSV@modified carriers indicated an inhibition of cell livability, when compared to the non-encapsulated drug. RSV@modified mesoporous carriers demonstrated cell viability inhibition better than RSV@mesoporous carriers. The inhibition of cell viability of RSV@modified mesoporous carriers depends on surface area and functionalized groups of carriers more than pore size. First order, Higuchi, HixsoneCrowell and KorsmeyerePeppas release kinetic models were applied to the experimental data and the release was found to obey a first-order rate kinetic. [GRAPHICS] .