The determination of dielectric constants of mixtures used in the treatment of epilepsy and the encapsulation of phenytoin in a titania matrix

被引:7
作者
Lopez, T.
Quintana, P.
Ascencio, J.
Gonzalez, R. D. [1 ]
机构
[1] Tulane Univ, Dept Chem & Biomol Engn, New Orleans, LA 70118 USA
[2] Univ Autonoma Metropolitana, Mexico City, DF, Mexico
[3] IPN, CINVESTAV, Unidad Merida, Merida 97310, Yucatan, Mexico
[4] Inst Mexicano Petr, Mexico City 07730, DF, Mexico
[5] Inst Nacl Neurol & Neurocirugia MVS, Mexico City, DF, Mexico
关键词
sol-gel reservoir; biocompatibility; dielectric constants; polarity; epilepsy;
D O I
10.1016/j.colsurfa.2006.10.061
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
In this study it is shown that an anticonvulsant drug such as phenytoin can successfully be encapsulated in a titania matrix. Infrared studies show that as a result of the encapsulation process, the structure of phenytoin is not chemically altered. BET studies show that the surface area of phenytoin is small in comparison to the surface area obtained following adsorption of the drug onto the surface of the titania. The dielectric constants of phenytoin, valproic acid and mixtures of the two were calculated. They were found to be independent of composition. Using stereotactic surgery the phenytoin/titania reservoir was implanted in the temporal lobe of the brain of a Winstar rat. Furthermore, the implanted device was found to be biocompatible with the surrounding tissue. An immunohistochemical study showed that chemical changes did not occur in the neurons surrounding the implant. Simulation studies show how to identify the pore size distribution required for the successful encapsulation of phenytoin. The formation of electrical dipoles within the titania matrix is discussed. (C) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:99 / 105
页数:7
相关论文
共 25 条
[1]  
ARVCAA HB, 2005, J CONTROL RELEASE, V102, P689
[2]  
Ascencio-Gutiérrez JA, 2000, AFINIDAD, V57, P180
[3]  
Bauer B, 2005, EXP BIOL MED, V230, P118
[4]   Potential role of ABC transporters as a detoxification system at the blood-CSF barrier [J].
de Lange, ECM .
ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (12) :1793-1809
[5]   ABC-transporters: implications on drug resistance from microorganisms to human cancers [J].
Lage, H .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2003, 22 (03) :188-199
[6]  
Liu XD, 2001, ACTA PHARMACOL SIN, V22, P111
[7]  
LOPEZ T, IN PRESS SURF COLL A
[8]  
LOPEZ VC, 2002, INT J PHARM, V23, P137
[9]   Current status and future directions in the pharmacotherapy of epilepsy [J].
Löscher, W .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (03) :113-118
[10]   Drug resistance in brain diseases and the role of drug efflux transporters [J].
Löscher, W ;
Potschka, H .
NATURE REVIEWS NEUROSCIENCE, 2005, 6 (08) :591-602