Nanofiltration membrane cascade for continuous solvent exchange

被引:80
|
作者
Lin, Justin Chun-Te [1 ]
Livingston, Andrew G. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem Engn & Chem Technol, London SW7 2AZ, England
关键词
solvent exchange; organic solvent nanofiltration; membrane; cascade;
D O I
10.1016/j.ces.2006.08.004
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
This paper proposes a continuous process for solvent exchange, a key unit operation for organic synthesis in pharmaceutical manufacturing. This process comprises a counter-current membrane cascade using organic solvent nanofiltration (OSN) membranes. The effect of process parameters, such as number of stages and flow rate ratio of replacing solvent to initial solvent, on solvent exchange performance are tested through simulations and experiments. Experimental results show 47.8%, 59.2%, and 75.3% solvent exchange for single-stage, two-stage and three-stage, cascades, values which are close to the 50.0%, 66.6%, and 75.0% predicted by simulations. In general, the feasibility of OSN membrane cascades for continuous solvent exchange is demonstrated in this work. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2728 / 2736
页数:9
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