A 4-item measure of depression and anxiety: Validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population

被引:1759
作者
Loewe, Bernd [1 ,2 ]
Wahl, Inka [1 ,2 ]
Rose, Matthias [1 ,2 ]
Spitzer, Carsten [1 ,2 ]
Glaesmer, Heide [3 ]
Wingenfeld, Katja [1 ,2 ]
Schneider, Antonius [4 ]
Braehler, Elmar [3 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Dept Psychosomat Med & Psychotherapy, D-20246 Hamburg, Germany
[2] Hamburg Eilbek Schon Clin, Hamburg, Germany
[3] Univ Leipzig, Dept Med Psychol & Med Sociol, Leipzig, Germany
[4] Univ Med Ctr, Dept Primary Care & Hlth Care Res, Heidelberg, Germany
关键词
Depression; Anxiety; Screening; Psychometrics; Validation studies; Patient Health Questionnaire (PHQ); DSM-IV DISORDERS; PRIMARY-CARE; MAJOR DEPRESSION; MENTAL-DISORDERS; PSYCHIATRIC-DISORDERS; HOSPITAL ANXIETY; FIT INDEXES; SELF-ESTEEM; PREVALENCE; VALIDITY;
D O I
10.1016/j.jad.2009.06.019
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The 4-item Patient Health Questionnaire-4 (PHQ-4) is an ultra-brief self-report questionnaire that consists of a 2-item depression scale (PHQ-2) and a 2-item anxiety scale (GAD-2). Given that PHQ-4, PHQ-2, and GAD-2 have not been validated in the general population, this study aimed to investigate their reliability and validity in a large general population sample and to generate normative data. Methods: A nationally representative face-to-face household survey was conducted in Germany in 2006. The survey questionnaire consisted of the PHQ-4, other self-report instruments, and demographic characteristics. Results: Of the 5030 participants (response rate = 72.9%), 53.6% were female and mean (SD) age was 48.4 (18.0) years. The sociodemographic characteristics of the study sample closely match those of the total populations in Germany as well as those in the United States. Confirmatory factor analyses showed very good fit indices for a two-factor solution (RMSEA .027: 90% CI .023-.032). All models tested were structurally invariant between different age and gender groups. Construct validity of the PHQ-4, PHQ-2, and GAD-2 was supported by intercorrelations with other self-report scales and with demographic risk factors for depression and anxiety. PHQ-2 and GAD-2 scores of 3 corresponded to percentile ranks of 93.4% and 95.2%, respectively, whereas PHQ-2 and GAD-2 scores of 5 corresponded to percentile ranks of 99.0% and 99.2%, respectively. Limitation: A criterion standard diagnostic interview for depression and anxiety was not included. Conclusions: Results from this study support the reliability and validity of the PHQ-4, PHQ-2, and GAD-2 as ultra-brief measures of depression and anxiety in the general population. The normative data provided in this study can be used to compare a subject's scale score with those determined from a general population reference group. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:86 / 95
页数:10
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