Dangerous Leaks: Blood-Brain Barrier Woes in the Aging Hippocampus

被引：37

作者：

Iadecola, Costantino ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Feil Family Brain & Mind Res Inst, New York, NY 10021 USA

来源：

NEURON | 2015年 / 85卷 / 02期

关键词：

AMYLOID-BETA; PERICYTES; DISEASE; HEALTH;

D O I：

10.1016/j.neuron.2014.12.056

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and neurodegeneration, but reliable human data were lacking. Here, Montagne et al. (2015) provide the first in vivo evidence of blood-brain barrier disruption in the aging hippocampus and in minimal cognitive impairment.

引用

页码：231 / 233

页数：3

共 15 条

[1] Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises [J].

Armulik, Annika ;

Genove, Guillem ;

Betsholtz, Christer .

DEVELOPMENTAL CELL, 2011, 21 (02) :193-215

[2] Mfsd2a is critical for the formation and function of the blood-brain barrier [J].

Ben-Zvi, Ayal ;

Lacoste, Baptiste ;

Kur, Esther ;

Andreone, Benjamin J. ;

Mayshar, Yoav ;

Yan, Han ;

Gu, Chenghua .

NATURE, 2014, 509 (7501) :507-+

[3] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[4] Capillary pericytes regulate cerebral blood flow in health and disease [J].

Hall, Catherine N. ;

Reynell, Clare ;

Gesslein, Bodil ;

Hamilton, Nicola B. ;

Mishra, Anusha ;

Sutherland, Brad A. ;

O'Farrell, Fergus M. ;

Buchan, Alastair M. ;

Lauritzen, Martin ;

Attwell, David .

NATURE, 2014, 508 (7494) :55-+

[5] The blood-brain barrier/neurovascular unit in health and disease [J].

Hawkins, BT ;

Davis, TP .

PHARMACOLOGICAL REVIEWS, 2005, 57 (02) :173-185

[6] The Pathobiology of Vascular Dementia [J].

Iadecola, Costantino .

NEURON, 2013, 80 (04) :844-866

[7] Blood-Brain Barrier Breakdown in the Aging Human Hippocampus [J].

Montagne, Axel ;

Barnes, Samuel R. ;

Sweeney, Melanie D. ;

Halliday, Matthew R. ;

Sagare, Abhay P. ;

Zhao, Zhen ;

Toga, Arthur W. ;

Jacobs, Russell E. ;

Liu, Collin Y. ;

Amezcua, Lilyana ;

Harrington, Michael G. ;

Chui, Helena C. ;

Law, Meng ;

Zlokovic, Berislav V. .

NEURON, 2015, 85 (02) :296-302

[8] Engaging neuroscience to advance translational research in brain barrier biology [J].

Neuwelt, Edward A. ;

Bauer, Bjoern ;

Fahlke, Christoph ;

Fricker, Gert ;

Iadecola, Constantino ;

Janigro, Damir ;

Leybaert, Luc ;

Molnar, Zoltan ;

O'Donnell, Martha E. ;

Povlishock, John T. ;

Saunders, Norman R. ;

Sharp, Frank ;

Stanimirovic, Danica ;

Watts, Ryan J. ;

Drewes, Lester R. .

NATURE REVIEWS NEUROSCIENCE, 2011, 12 (03) :169-182

[9] Development, maintenance and disruption of the blood-brain barrier [J].

Obermeier, Birgit ;

Daneman, Richard ;

Ransohoff, Richard M. .

NATURE MEDICINE, 2013, 19 (12) :1584-1596

[10] The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction [J].

Park, L. ;

Wang, G. ;

Moore, J. ;

Girouard, H. ;

Zhou, P. ;

Anrather, J. ;

Iadecola, C. .

NATURE COMMUNICATIONS, 2014, 5

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