Effects of oxytocin and prostaglandin F2α (enzaprost) on platelet aggregation

被引：6

作者：

Ailamazyan, EK ^{[1
]}

Petrishchev, NN ^{[1
]}

Vivulanets, EV ^{[1
]}

Maryutina, LV ^{[1
]}

Mindukshev, IV ^{[1
]}

Khachaturyan, AR ^{[1
]}

机构：

[1] IP Pavlov St Petersburg State Med Univ, IM Setchenov Inst Evolut Physiol & Biochem, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 134卷 / 05期

关键词：

platelet aggregation; oxytocin; prostaglandin F-2 alpha; pregnancy; labor;

D O I：

10.1023/A:1022677927836

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of uterotonic agents (oxytocin and enzaprost) on platelet aggregation in pregnant and nonpregnant women were studied by low-angle light scattering. In nonpregnant women oxytocin produced different effects on ADP-induced platelet aggregation: potentiation at low (<200 nM) and inhibition at high (>400 nM) ADP concentrations. In pregnant women oxytocin did not modulate ADP-induced platelet aggregation or this effect was negligible. Enzaprost competitively inhibited ADP-induced platelet aggregation in all examined women (inhibition constant 84.8+/-25.7 nM).

引用

页码：439 / 441

页数：3

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