Dopamine, depression and antidepressants

被引：247

作者：

Dailly, E ^{[1
]}

Chenu, F ^{[1
]}

Renard, CE ^{[1
]}

Bourin, M ^{[1
]}

机构：

[1] Fac Med, EA 3256, F-44035 Nantes 01, France

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2004年 / 18卷 / 06期

关键词：

antidepressants; depression; dopamine;

D O I：

10.1111/j.1472-8206.2004.00287.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The relationship between depression and dopamine deficiency in the mesolimbic pathway has been hypothesized for many years. The experimental studies with animal models of depression and the human studies implicate the role of the dopamine system in depression. Not only do dopaminergic receptor agonists, but also antagonists such as olanzapine exhibit antidepressant effects associated with standard antidepressants in patients with treatment-resistant depression. This paradoxical result suggests that further investigations are necessary to understand the role played by dopamine in depression.

引用

页码：601 / 607

页数：7

共 66 条

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