Methods and Challenges in Quantitative Imaging Biomarker Development

被引：70

作者：

Abramson, Richard G. ^{[1
]}

Burton, Kirsteen R. ^{[2
,3
]}

Yu, John-Paul J. ^{[4
]}

Scalzetti, Ernest M. ^{[5
]}

Yankee, Thomas E. ^{[6
]}

Rosenkrantz, Andrew B. ^{[7
]}

Mendiratta-Lala, Mishal ^{[8
]}

Barth, Brian J. ^{[9
]}

Ganeshan, Dhakshinamoorthy ^{[10
]}

Lenchik, Leon ^{[11
]}

Subramaniam, Rathan M. ^{[12
,13
]}

机构：

[1] Vanderbilt Univ, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA

[2] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada

[3] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

[4] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[5] SUNY Upstate Med Univ, Dept Radiol, Syracuse, NY 13210 USA

[6] Vanderbilt Univ, Inst Imaging Sci, Nashville, TN 37232 USA

[7] NYU, Dept Radiol, Langone Med Ctr, New York, NY 10016 USA

[8] Henry Ford Hosp, Abdominal & Cross Sect Intervent Radiol, Detroit, MI 48202 USA

[9] Mayo Clin, Div Radiol Informat, Rochester, MN USA

[10] Univ Texas MD Anderson Canc Ctr, Dept Abdominal Imaging, Houston, TX 77030 USA

[11] Wake Forest Sch Med, Dept Radiol, Winston Salem, NC USA

[12] Johns Hopkins Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

[13] Johns Hopkins Univ, Dept Hlth Policy & Management, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA

来源：

ACADEMIC RADIOLOGY | 2015年 / 22卷 / 01期

基金：

美国国家卫生研究院; 美国医疗保健研究与质量局;

关键词：

Radiology; quantitative imaging; biomarker development; CONTRAST-ENHANCED MRI; CLINICAL-TRIAL DESIGNS; TUMOR RESPONSE; BREAST-CANCER; MURINE MODEL; REPRODUCIBILITY; VALIDATION; RADIOLOGY; CHEMOTHERAPY; MICROPET;

D O I：

10.1016/j.acra.2014.09.001

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Academic radiology is poised to play an important role in the development and implementation of quantitative imaging (QI) tools. This article, drafted by the-Association of University Radiologists Radiology Research Alliance Quantitative Imaging Task Force, reviews current issues in QI biomarker research. We discuss motivations for advancing QI, define key terms, present a framework for QI biomarker research, and outline challenges in QI biomarker development. We conclude by describing where QI research and development is currently taking place and discussing the paramount role of academic radiology in this rapidly evolving field.

引用

页码：25 / 32

页数：8

共 83 条

[1] Informatics in Radiology Improving Clinical Work Flow through an AIM Database: A Sample Web-based Lesion Tracking Application [J].

Abajian, Aaron C. ;

Levy, Mia ;

Rubin, Daniel L. .

RADIOGRAPHICS, 2012, 32 (05) :1543-1552

[2]

Abramson RG, 2014, FUNCTIONAL IMAGING O

[3] Quantitative metrics in clinical radiology reporting: a snapshot perspective from a single mixed academic-community practice [J].

Abramson, Richard G. ;

Su, Pei-Fang ;

Shyr, Yu .

MAGNETIC RESONANCE IMAGING, 2012, 30 (09) :1357-1366

[4] Reproducibility and Correlation Between Quantitative and Semiquantitative Dynamic and Intrinsic Susceptibility-Weighted MRI Parameters in the Benign and Malignant Human Prostate [J].

Alonzi, Roberto ;

Taylor, N. Jane ;

Stirling, J. James ;

d'Arcy, James A. ;

Collins, David J. ;

Saunders, Michele I. ;

Hoskin, Peter J. ;

Padhani, Anwar R. .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2010, 32 (01) :155-164

[5]

[Anonymous], EV BIOM SURR ENDP CH

[6]

Arksey H., 2005, INT J SOC RES METHOD, V8, P19, DOI DOI 10.1080/1364557032000119616

[7] Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].

Atkinson, AJ ;

Colburn, WA ;

DeGruttola, VG ;

DeMets, DL ;

Downing, GJ ;

Hoth, DF ;

Oates, JA ;

Peck, CC ;

Schooley, RT ;

Spilker, BA ;

Woodcock, J ;

Zeger, SL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95

[8] Assessing the reproducibility of dynamic contrast enhanced magnetic resonance imaging in a murine model of breast cancer [J].

Barnes, Stephanie L. ;

Whisenant, Jennifer G. ;

Loveless, Mary E. ;

Ayers, Gregory D. ;

Yankeelov, Thomas E. .

MAGNETIC RESONANCE IN MEDICINE, 2013, 69 (06) :1721-1734

[9]

Beaton D E, 2001, J Hand Ther, V14, P128

[10] Cancerous Breast Lesions on Dynamic Contrast-enhanced MR Images: Computerized Characterization for Image-based Prognostic Markers [J].

Bhooshan, Neha ;

Giger, Maryellen L. ;

Jansen, Sanaz A. ;

Li, Hui ;

Lan, Li ;

Newstead, Gillian M. .

RADIOLOGY, 2010, 254 (03) :680-690

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