Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin

被引：5

作者：

Akoulina, E. A. ^{[1
]}

Demianova, I. V. ^{[1
]}

Zharkova, I. I. ^{[1
]}

Voinova, V. V. ^{[1
]}

Zhuikov, V. A. ^{[2
]}

Khaydapova, D. D. ^{[3
]}

Chesnokova, D. V. ^{[1
]}

Menshikh, K. A. ^{[1
]}

Dudun, A. A. ^{[2
]}

Makhina, T. K. ^{[2
]}

Bonartseva, G. A. ^{[2
]}

Volkov, A. V. ^{[3
]}

Asfarov, T. F. ^{[3
]}

Ivanov, S. Y. ^{[3
,4
]}

Shaitan, K. V. ^{[1
]}

Bonartsev, A. P. ^{[1
,2
]}

机构：

[1] MV Moscow State Univ, Fac Biol, Moscow, Russia

[2] Russian Acad Sci, Fed Res Ctr Fundamentals Biotechnol, AN Bach Inst Biochem, Moscow, Russia

[3] Peoples Friendship Univ Russia RUDN Univ, Moscow, Russia

[4] Sechenov Univ, IM Sechenov First Moscow State Med Univ, Minist Hlth Russian Federat, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 171卷 / 01期

关键词：

poly(3-hydroxybutyrate); simvastatin; hydroxyapatite; scaffolds; osteoinductive; POROSITY;

D O I：

10.1007/s10517-021-05190-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of porous composite scaffolds based on poly(3-hydroxybutyrate) (PHB) loaded with simvastatin on the growth and differentiation of mesenchymal stem cells. The scaffolds have a suitable microstructure (porosity and pore size) and physicochemical properties to support the growth of mesenchymal stem cells. Scaffold loading with simvastatin suppressed cell growth and increased alkaline phosphatase activity, which can attest to their osteoinductive properties.

引用

页码：172 / 177

页数：6

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