Thielavins W-Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

被引：9
作者：
Han, Zhuang [1 ,2 ]
Li, Yong-Xin [2 ]
Liu, Ling-Li [2 ]
Lu, Liang [2 ]
Guo, Xian-Rong [3 ]
Zhang, Xi-Xiang [4 ]
Zhang, Xiao-Yong [5 ]
Qi, Shu-Hua [5 ]
Xu, Ying [2 ,6 ]
Qian, Pei-Yuan [2 ]
机构：
[1] Chinese Acad Sci, Inst Deep Sea Sci & Engn, 28 Luhuitou Rd, Sanya 572000, Peoples R China
[2] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
[3] King Abdullah Univ Sci & Technol, Imaging & Characterizat Core Lab, Thuwal 239556900, Saudi Arabia
[4] King Abdullah Univ Sci & Technol, Phys Sci & Engn, Thuwal 239556900, Saudi Arabia
[5] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
[6] Shenzhen Univ, Coll Life Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China
来源：
MARINE DRUGS | 2017年 / 15卷 / 05期
关键词：
marine-derived fungus; Thielavia sp; antifouling; Balanus (=Amphibalanus) amphitrite; thielavins; BALANUS-AMPHITRITE; INHIBITORS; SETTLEMENT; COMPOUND;
D O I：
10.3390/md15050128
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Eleven new depsides-thielavins W-Z (1-4) and thielavins Z(1)-Z(7) (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 +/- 0.59 to 69.19 +/- 9.51 mu M, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
引用
收藏
页数：12
相关论文
共 20 条
  • [11] Fungal communities from methane hydrate-bearing deep-sea marine sediments in South China Sea
    Lai, Xintian
    Cao, Lixiang
    Tan, Hongming
    Fang, Shu
    Huang, Yali
    Zhou, Shining
    [J]. ISME JOURNAL, 2007, 1 (08) : 756 - 762
  • [12] Structural optimization and evaluation of butenolides as potent antifouling agents: modification of the side chain affects the biological activities of compounds
    Li, Yongxin
    Zhang, Fengying
    Xu, Ying
    Matsumura, Kiyotaka
    Han, Zhuang
    Liu, Lingli
    Lin, Wenhan
    Jia, Yanxing
    Qian, Pei-Yuan
    [J]. BIOFOULING, 2012, 28 (08) : 857 - 864
  • [13] Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus -: Cell wall transglycosylation inhibitors in Enterococcus
    Mani, N
    Sanchet, P
    Jiang, ZD
    McNaney, C
    DeCenzo, M
    Knighti, B
    Stankis, M
    Kuranda, M
    Rothstein, DM
    [J]. JOURNAL OF ANTIBIOTICS, 1998, 51 (05) : 471 - 479
  • [14] Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: Producing strain, fermentation, isolation, structural elucidation and biological activities
    Sakemi, S
    Hirai, H
    Ichiba, T
    Inagaki, T
    Kato, Y
    Kojima, N
    Nishida, H
    Parker, JC
    Saito, T
    Tonai-Kachi, H
    VanVolkenburg, MA
    Yoshikawa, N
    Kojima, Y
    [J]. JOURNAL OF ANTIBIOTICS, 2002, 55 (11) : 941 - 951
  • [15] Non-toxic alternative compounds for marine antifouling paints
    Stupak, ME
    García, MT
    Pérez, MC
    [J]. INTERNATIONAL BIODETERIORATION & BIODEGRADATION, 2003, 52 (01) : 49 - 52
  • [16] Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B
    Togashi, K
    Ko, HR
    Ahn, JS
    Osada, H
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2001, 65 (03) : 651 - 653
  • [17] Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds
    Wang, Kai-Ling
    Xu, Ying
    Lu, Liang
    Li, Yongxin
    Han, Zhuang
    Zhang, Jun
    Shao, Chang-Lun
    Wang, Chang-Yun
    Qian, Pei-Yuan
    [J]. MARINE BIOTECHNOLOGY, 2015, 17 (05) : 624 - 632
  • [18] Potent antifouling compounds produced by marine Streptomyces
    Xu, Ying
    He, Hongping
    Schulz, Stefan
    Liu, Xin
    Fusetani, Nobushino
    Xiong, Hairong
    Xiao, Xiang
    Qian, Pei-Yuan
    [J]. BIORESOURCE TECHNOLOGY, 2010, 101 (04) : 1331 - 1336
  • [19] Inhibitory Effects of a Branched-Chain Fatty Acid on Larval Settlement of the Polychaete Hydroides elegans
    Xu, Ying
    Li, Honglei
    Li, Xiancui
    Xiao, Xiang
    Qian, Pei-Yuan
    [J]. MARINE BIOTECHNOLOGY, 2009, 11 (04) : 495 - 504
  • [20] Effect of Size, Shape, and Surface Modification on Cytotoxicity of Gold Nanoparticles to Human HEp-2 and Canine MDCK Cells
    Zhang, Yinan
    Xu, Dan
    Li, Wenqin
    Yu, Jun
    Chen, Yu
    [J]. JOURNAL OF NANOMATERIALS, 2012, 2012
12