A genetic signature of the evolution of loss of flight in the Galapagos cormorant

被引：56

作者：

Burga, Alejandro ^{[1
,2
]}

Wang, Weiguang ^{[3
,4
]}

Ben-David, Eyal ^{[1
,2
]}

Wolf, Paul C. ^{[5
]}

Ramey, Andrew M. ^{[6
]}

Verdugo, Claudio ^{[7
]}

Lyons, Karen ^{[3
,4
]}

Parker, Patricia G. ^{[8
,9
,10
]}

Kruglyak, Leonid ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Dept Biol Chem, Dept Human Genet, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA USA

[5] USDA, Wildlife Serv, Roseburg, OR USA

[6] US Geol Survey, Alaska Sci Ctr, Anchorage, AK USA

[7] Univ Austral Chile, Fac Ciencias Vet, Inst Patol Anim, Valdivia, Chile

[8] Univ Missouri, Dept Biol, 8001 Nat Bridge Rd, St Louis, MO 63121 USA

[9] Univ Missouri, Whitney Harris World Ecol Ctr, St Louis, MO 63121 USA

[10] St Louis Zoo, WildCare Inst, St Louis, MO USA

来源：

SCIENCE | 2017年 / 356卷 / 6341期

关键词：

PLANAR CELL POLARITY; HOMEODOMAIN PROTEIN; PRIMARY CILIUM; CUX1; EXPRESSION; MUTATIONS; FLIGHTLESSNESS; DIFFERENTIATION; CILIOGENESIS; TRAFFICKING;

D O I：

10.1126/science.aal3345

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have a limited understanding of the genetic and molecular basis of evolutionary changes in the size and proportion of limbs. We studied wing and pectoral skeleton reduction leading to flightlessness in the Galapagos cormorant (Phalacrocorax harrisi). We sequenced and de novo assembled the genomes of four cormorant species and applied a predictive and comparative genomics approach to find candidate variants that may have contributed to the evolution of flightlessness. These analyses and cross-species experiments in Caenorhabditis elegans and in chondrogenic cell lines implicated variants in genes necessary for transcriptional regulation and function of the primary cilium. Cilia are essential for Hedgehog signaling, and humans affected by skeletal ciliopathies suffer from premature bone growth arrest, mirroring skeletal features associated with loss of flight.

引用

页数：8

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