Recent Progress in the Functionalization of Benzo-γ-Pyrones via Transition-Metal Catalyzed Cross-Coupling Reactions

被引：2
作者：
Ming, Xianjun [1 ]
Yang, Kan [1 ]
Gao, Biao [1 ]
Gu, Qinlan [2 ]
Wang, Jinxin [1 ]
机构：
[1] China Pharmaceut Univ, Key Lab Drug Design & Optimizat Jiangsu Prov, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Higher Vocat & Tech Coll, Nanjing 210009, Jiangsu, Peoples R China
来源：
MINI-REVIEWS IN ORGANIC CHEMISTRY | 2016年 / 13卷 / 01期
关键词：
Benzo-gamma-pyrone; carbon-carbon bond; cross-coupling; natural products; palladium-catalyzed; vinyl halides/triflates; BIOLOGICAL EVALUATION; SUZUKI-MIYAURA; CHROMONE DERIVATIVES; C-C; POTENT; INHIBITORS; DESIGN; FLAVONES; ANALOGS; GLAZIOVIANIN;
D O I：
10.2174/1570193X13666160225000421
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzo-gamma-pyrone derivatives have attracted increasing attentions due to their significant biological activities. Structural modifications based on benzo-gamma-pyrone scaffold are being carried out in several ways in order to anticipate enhanced biological activities. This review mainly covers recent studies on the functionalization of benzo-gamma-pyrone scaffold by using different transition-metalcatalyzed cross-coupling reactions, which provides an in depth view of diversity-oriented synthesis of benzo-gamma-pyrone derivatives.
引用
收藏
页码：31 / 48
页数：18
相关论文
共 72 条
[1]   Chemoselective Suzuki-Miyaura Cross-Coupling Reactions of 6-Bromo-3-(trifluoromethylsulfonyloxy)flavone [J].
Akrawi, Omer A. ;
Patonay, Tamas ;
Konya, Krisztina ;
Langer, Peter .
SYNLETT, 2013, 24 (07) :860-864
[2]   Synthesis of arylated xanthones by site-selective Suzuki-Miyaura reactions of the bis(triflate) of 1,3-dihydroxyxanthone [J].
Akrawi, Omer A. ;
Mohammed, Hamid H. ;
Patonay, Tamas ;
Villinger, Alexander ;
Langer, Peter .
TETRAHEDRON, 2012, 68 (31) :6298-6304
[3]   An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin [J].
Biegasiewicz, Kyle F. ;
St Denis, Jeffrey D. ;
Carroll, Vincent M. ;
Priefer, Ronny .
TETRAHEDRON LETTERS, 2010, 51 (33) :4408-4410
[4]   Strategies for Coupling Molecular Units if Subsequent Decoupling Is Required [J].
Bielski, Roman ;
Witczak, Zbigniew .
CHEMICAL REVIEWS, 2013, 113 (03) :2205-2243
[5]   Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists [J].
Biswas, Kaustav ;
Peterkin, Tanya A. N. ;
Bryan, Marian C. ;
Arik, Leyla ;
Lehto, Sonya G. ;
Sun, Hong ;
Hsieh, Feng-Yin ;
Xu, Cen ;
Fremeau, Robert T. ;
Allen, Jennifer R. .
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (20) :7232-7246
[6]   Chromenones as potent bradykinin B1 antagonists [J].
Bryan, Marian C. ;
Biswas, Kaustav ;
Peterkin, Tanya A. N. ;
Rzasa, Robert M. ;
Arik, Leyla ;
Lehto, Sonya G. ;
Sun, Hong ;
Hsieh, Feng-Yin ;
Xu, Cen ;
Fremeau, Robert T. ;
Allen, Jennifer R. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (01) :619-622
[7]   Microwave-assisted solvent-free N-arylation of imidazole and pyrazole [J].
Chow, Wai Shan ;
Chan, Tak Hang .
TETRAHEDRON LETTERS, 2009, 50 (12) :1286-1289
[8]   A scaffold approach to 3,6,8-trisubstituted flavones [J].
Dahlén, K ;
Grotli, M ;
Luthman, K .
SYNLETT, 2006, (06) :897-900
[9]   Microwave-assisted Suzuki-Miyaura and Heck-Mizoroki cross-coupling reactions of aryl chlorides and bromides in water using stable benzothiazole-based palladium(II) precatalysts [J].
Dawood, Kamal M. .
TETRAHEDRON, 2007, 63 (39) :9642-9651
[10]   Design, Synthesis, and Biological Evaluation of Chromone-Based p38 MAP Kinase Inhibitors [J].
Dyrager, Christine ;
Mollers, Linda Nilsson ;
Kjall, Linda Karlsson ;
Alao, John Patrick ;
Diner, Peter ;
Wallner, Fredrik K. ;
Sunnerhagen, Per ;
Grotli, Morten .
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (20) :7427-7431
12345678