Three new lignanamides from the root of Lycium chinense with anti-inflammatory activity

被引：17

作者：

Chen, Fang ^{[1
]}

Huang, Xiao-jun ^{[1
]}

Liang, Qiu-ping ^{[1
]}

Huang, Yuan-peng ^{[1
]}

Lan, Ting ^{[1
]}

Zhou, Guang-xiong ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Lycium chinense; lignanamide; enantiomer; ECD calculations; anti-inflammatory activity; BARK; GLYCOSIDES;

D O I：

10.1080/14786419.2018.1478830

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new lignanamides, that is, a new lignanamide (1), and a pair of enantiomers (2a and 2b) were isolated from the EtOAc-soluble fraction of an EtOH extract of the root of Lycium chinense. The structures of these new compounds, including their absolute configuration, were established on the basis of HR-ESI-MS, NMR spectroscopic data and quantum chemical ECD calculations. Compound 2a showed significant anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC50 value of 10.77???2.14??M, comparing to that of positive control quercetin (17.21???0.50??M).

引用

收藏

页码：3378 / 3382

页数：5

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