Role of TCF-1 in differentiation, exhaustion, and memory of CD8+ T cells: A review

被引：49
作者：
Zhang, Jiaxue [1 ]
Lyu, Tong [2 ]
Cao, Yaming [2 ]
Feng, Hui [2 ]
机构：
[1] China Med Univ, Clin Med Fac 1, Shenyang, Liaoning, Peoples R China
[2] China Med Univ, Coll Basic Med Sci, Dept Immunol, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China
来源：
FASEB JOURNAL | 2021年 / 35卷 / 05期
关键词：
cancer; CD8(+) T cells; exhaustion; immune memory; TCF-1; viral Infection; ALLERGIC RHINITIS MODEL; AIRWAY INFLAMMATION; MURINE MODEL; SUBSTANCE-P; CHANNEL TRPA1; GUINEA-PIG; ASTHMA; CHALLENGE; EXPRESSION; RESPONSIVENESS;
D O I：
10.1096/fj.202002566R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
T cell factor-1 (TCF-1) (encoded by the TCF7 gene) is a transcription factor that plays important role during the T cell development and differentiation for T cell to exercise its functions including producing memory T cells. Not only TCF-1 can modulate the T cell development but also exerts various effects on the differentiation and function of mature CD8(+) T cells. In addition, it drives the production and maintenance of the immune response of CD8(+) T cells after PD-1 checkpoint blockade therapy. TCF-1 can serve as a potential target of immunotherapy and may provide promising novel treatment strategies for patients with cancer and infections. Moreover, TCF-1 is a potential biomarker of CD8(+) T cell functionality to predict the efficacy of immunotherapy in fighting against cancer and infections. Herein, we summarize the role of TCF-1 in T cell development and its applications in the treatment of cancer and infectious diseases.
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页数：12
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