From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology

被引：129

作者：

Natarajan, Niranjana ^{[1
]}

Pluznick, Jennifer L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21205 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2014年 / 307卷 / 11期

关键词：

Gpr41; Gpr43; microbiota; Olfr78; SCFAs; PROTEIN-COUPLED RECEPTOR; HISTONE DEACETYLASE INHIBITORS; INTESTINAL EPITHELIAL-CELLS; DIET-INDUCED OBESITY; GUT MICROBIOTA; COLON-CANCER; NICOTINIC-ACID; MOLECULAR CHARACTERIZATION; INFLAMMATORY RESPONSES; SODIUM-BUTYRATE;

D O I：

10.1152/ajpcell.00228.2014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have highlighted a myriad of ways in which the activity and composition of the gut microbiota can affect the host organism. A primary way in which the gut microbiota affect host physiology is by the production of metabolites, such as short-chain fatty acids (SCFAs), which are subsequently absorbed into the bloodstream of the host. Although recent studies have begun to unravel the ways in which gut microbial SCFAs affect host physiology, less is understood regarding the underlying cell biological mechanisms. In this review, we will outline the known receptors and transporters for SCFAs, and review what is known about the cell biological effects of microbial SCFAs.

引用

页码：C979 / C985

页数：7

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